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Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
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FRONTIERS IN IMMUNOLOGY (2017)
EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity
Diana I. Albu et al.
ONCOIMMUNOLOGY (2017)
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
Susanne M. Steggerda et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)
The Feasibility and safety of surgery in Patients receiving immune checkpoint inhibitors: a retrospective study
Alexandra W. Elias et al.
FRONTIERS IN ONCOLOGY (2017)
Metabolic Cooperation and Competition in the Tumor Microenvironment: implications for Therapy
Seema Gupta et al.
FRONTIERS IN ONCOLOGY (2017)
The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO
Giada Mondanelli et al.
CURRENT OPINION IN PHARMACOLOGY (2017)
LAG-3+tumor infiltrating lymphocytes in breast cancer: clinical correlates and association with PD-1/PD-L1+tumors
S. Burugu et al.
ANNALS OF ONCOLOGY (2017)
CX-1158-101: A first-in-human phase 1 study of CB-1158, a small molecule inhibitor of arginase, as monotherapy and in combination with an anti-PD-1 checkpoint inhibitor in patients (pts) with solid tumors.
Kyriakos P. Papadopoulos et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Epacadostat plus nivolumab in patients with advanced solid tumors: Preliminary phase I/II results of ECHO-204.
Raymond P. Perez et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Epacadostat plus pembrolizumab in patients with advanced urothelial carcinoma: Preliminary phase I/II results of ECHO-202/KEYNOTE-037.
David C. Smith et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Efficacy/safety of epacadostat plus pembrolizumab in triple-negative breast cancer and ovarian cancer: Phase I/II ECHO-202 study
Alexander I. Spira et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Safety and clinical activity of adenosine A2a receptor (A2aR) antagonist, CPI-444, in anti-PD1/PDL1 treatment-refractory renal cell (RCC) and non-small cell lung cancer (NSCLC) patients.
Lawrence Fong et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Epacadostat plus pembrolizumab in patients with SCCHN: Preliminary phase VII results from ECHO-202/KEYNOTE-037.
Omid Hamid et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
A phase Ib dose escalation study of combined inhibition of IDO1 (GDC-0919) and PD-L1 (atezolizumab) in patients (pts) with locally advanced or metastatic solid tumors
Howard A. Burris et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Targeting immunosuppressive adenosine in cancer (vol 17, pg 709, 2017)
Dipti Vijayan et al.
NATURE REVIEWS CANCER (2017)
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor
Tomasz Maj et al.
NATURE IMMUNOLOGY (2017)
Efficacy and safety of epacadostat plus pembrolizumab treatment of NSCLC: Preliminary phase I/II results of ECHO-202/KEYNOTE-037
Tara C. Gangadhar et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Metabolic reprogramming and apoptosis sensitivity: Defining the contours of a T cell response
Kelsey Voss et al.
CANCER LETTERS (2017)
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
Ying Zhang et al.
CANCER CELL (2017)
The role of AMPK in T cell metabolism and function
Eric H. Ma et al.
CURRENT OPINION IN IMMUNOLOGY (2017)
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Pu-Ste Liu et al.
NATURE IMMUNOLOGY (2017)
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer
Anusha-Preethi Ganesan et al.
NATURE IMMUNOLOGY (2017)
Amino-acid sensing and degrading pathways in immune regulation
Ursula Grohmann et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2017)
First-in-Human Phase I Study of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in Patients with Advanced Solid Malignancies
Gregory L. Beatty et al.
CLINICAL CANCER RESEARCH (2017)
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Alessia Angelin et al.
CELL METABOLISM (2017)
Pembrolizumab in patients with recurrent thymic carcinoma: Results of a phase II study.
Giuseppe Giaccone et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Epacadostat plus pembrolizumab in patients with advanced RCC: Preliminary phase I/II results from ECHO-202/KEYNOTE-037.
Primo Lara et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Combination therapy with L-arginine and α-PD-L1 antibody boosts immune response against osteosarcoma in immunocompetent mice
Xiaojun He et al.
CANCER BIOLOGY & THERAPY (2017)
Dendritic cells in cancer: the role revisited
Filippo Veglia et al.
CURRENT OPINION IN IMMUNOLOGY (2017)
Radiotherapy in combination with immune checkpoint inhibitors
Dirk De Ruysscher et al.
CURRENT OPINION IN ONCOLOGY (2017)
Gsk3 is a metabolic checkpoint regulator in B cells
Julia Jellusova et al.
NATURE IMMUNOLOGY (2017)
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
Shari Pilon-Thomas et al.
CANCER RESEARCH (2016)
Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis
Naomi Tsurutani et al.
JOURNAL OF IMMUNOLOGY (2016)
Understanding the role of the kynurenine pathway in human breast cancer immunobiology
Benjamin Heng et al.
ONCOTARGET (2016)
Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity
Yongkui Li et al.
ONCOIMMUNOLOGY (2016)
Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
Sangbin Lim et al.
CANCER RESEARCH (2016)
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Roger Geiger et al.
CELL (2016)
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
Rigel J. Kishton et al.
CELL METABOLISM (2016)
Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial
Antonin Levy et al.
EUROPEAN JOURNAL OF CANCER (2016)
mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
Hu Zeng et al.
IMMUNITY (2016)
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
Ana C. Anderson et al.
IMMUNITY (2016)
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
Frank A. Schildberg et al.
IMMUNITY (2016)
Targeting PD-1 and Tim-3 Pathways to Reverse CD8 T-Cell Exhaustion and Enhance Ex Vivo T-Cell Responses to Autologous Dendritic/Tumor Vaccines
Jingwei Liu et al.
JOURNAL OF IMMUNOTHERAPY (2016)
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
Wei Yang et al.
NATURE (2016)
Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
Min Peng et al.
SCIENCE (2016)
COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis
Mousumi Majumder et al.
STEM CELLS (2016)
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Chia-Wei Li et al.
NATURE COMMUNICATIONS (2016)
Improved Efficacy of Neoadjuvant Compared to Adjuvant Immunotherapy to Eradicate Metastatic Disease
Jing Liu et al.
CANCER DISCOVERY (2016)
A Phase I study of indoximod in patients with advanced malignancies
Hatem H. Soliman et al.
ONCOTARGET (2016)
Immunological Mechanisms Underneath the Efficacy of Cancer Therapy
Lorenzo Galluzzi et al.
CANCER IMMUNOLOGY RESEARCH (2016)
Targeting CD73 in the tumor microenvironment with MEDI9447
Carl M. Hay et al.
ONCOIMMUNOLOGY (2016)
Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
Ping-Chih Ho et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)
Increased expression of IDO associates with poor postoperative clinical outcome of patients with gastric adenocarcinoma
Hao Liu et al.
SCIENTIFIC REPORTS (2016)
A phase II study of pembrolizumab in patients with recurrent thymic carcinoma.
Giuseppe Giaccone et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
Targeting 6-phosphofructo-2-kinase (PFKFB3) as an immunotherapeutic strategy.
Jason Alan Chesney et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
From Krebs to clinic: glutamine metabolism to cancer therapy (vol 16, pg 619, 2016)
Brian J. Altman et al.
NATURE REVIEWS CANCER (2016)
Regulatory circuits of T cell function in cancer
Daniel E. Speiser et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
Chunming Cheng et al.
CANCER CELL (2015)
Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer
Jin Peng et al.
CANCER RESEARCH (2015)
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang et al.
CELL (2015)
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
Santiago Zelenay et al.
CELL (2015)
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Beth Kelly et al.
CELL RESEARCH (2015)
Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival
Ulf H. Beier et al.
FASEB JOURNAL (2015)
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine
Aiden Haghikia et al.
IMMUNITY (2015)
TIGIT and PD-1 impair tumor antigen-specific CD8+ T cells in melanoma patients
Joe-Marc Chauvin et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
TIGIT predominantly regulates the immune response via regulatory T cells
Sema Kurtulus et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression
Tingting Pan et al.
MEDIATORS OF INFLAMMATION (2015)
Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection
Jonathan H. Chen et al.
NATURE MEDICINE (2015)
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
D. T. Le et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset
Karin Larsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz et al.
SCIENCE SIGNALING (2015)
Targeting T cell metabolism for therapy
David O'Sullivan et al.
TRENDS IN IMMUNOLOGY (2015)
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
Duygu Sag et al.
NATURE COMMUNICATIONS (2015)
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
Nikolaos Patsoukis et al.
NATURE COMMUNICATIONS (2015)
Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
Claudia Sorrentino et al.
ONCOTARGET (2015)
LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
Ruea-Yea Huang et al.
ONCOTARGET (2015)
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz et al.
SCIENCE SIGNALING (2015)
Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway
J. Park et al.
MUCOSAL IMMUNOLOGY (2015)
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Yu-Hwa Huang et al.
NATURE (2015)
Mesothelioma Tumor Cells Modulate Dendritic Cell Lipid Content, Phenotype and Function
Joanne K. Gardner et al.
PLOS ONE (2015)
The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro
Johan A. Carlsson et al.
PLOS ONE (2015)
Dendritic cell metabolism
Edward J. Pearce et al.
NATURE REVIEWS IMMUNOLOGY (2015)
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity
Jacques C. Mbongue et al.
VACCINES (2015)
Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism
Marta Yanina Pepino et al.
ANNUAL REVIEW OF NUTRITION, VOL 34 (2014)
Targeting Glucose Metabolism in Patients With Cancer
Shannon E. Elf et al.
CANCER (2014)
The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function
Robert J. Johnston et al.
CANCER CELL (2014)
Biochemical Signaling of PD-1 on T Cells and Its Functional Implications
Vassiliki A. Boussiotis et al.
CANCER JOURNAL (2014)
2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
Dongsheng Zhang et al.
CANCER LETTERS (2014)
An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer
Song Xu et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2014)
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
L. Bracci et al.
CELL DEATH AND DIFFERENTIATION (2014)
The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
Andrew N. Macintyre et al.
CELL METABOLISM (2014)
Metabolism of activated T lymphocytes
Jason A. Maciolek et al.
CURRENT OPINION IN IMMUNOLOGY (2014)
Enhanced suppressor function of TIM-3+FoxP3+ regulatory T cells
Anne-Sophie Gautron et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2014)
Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses
Nicole Joller et al.
IMMUNITY (2014)
Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
David O'Sullivan et al.
IMMUNITY (2014)
Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE
Alex J. Freemerman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion
Robert L. Ferris et al.
JOURNAL OF IMMUNOLOGY (2014)
Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation
Mathieu Gigoux et al.
MOLECULAR IMMUNOLOGY (2014)
Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
Julia M. Marchingo et al.
SCIENCE (2014)
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
Francis Mussai et al.
BLOOD (2013)
VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer
Magali Terme et al.
CANCER RESEARCH (2013)
Benefits of Vascular Normalization Are Dose and Time Dependent-Letter
Yuhui Huang et al.
CANCER RESEARCH (2013)
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang et al.
CELL (2013)
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock et al.
CELL (2013)
Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs
Bertrand Allard et al.
CLINICAL CANCER RESEARCH (2013)
Sustained Interactions between T Cell Receptors and Antigens Promote the Differentiation of CD4+ Memory T Cells
Chulwoo Kim et al.
IMMUNITY (2013)
Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model
Xiufen Zheng et al.
INTERNATIONAL JOURNAL OF CANCER (2013)
Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas
Jing Zeng et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2013)
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Madhusudhanan Sukumar et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid
Aikaterini Nasi et al.
JOURNAL OF IMMUNOLOGY (2013)
Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
Zaheed Husain et al.
JOURNAL OF IMMUNOLOGY (2013)
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
G. M. Tannahill et al.
NATURE (2013)
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
Andrew L. Doedens et al.
NATURE IMMUNOLOGY (2013)
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Yoko Kidani et al.
NATURE IMMUNOLOGY (2013)
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
Linda V. Sinclair et al.
NATURE IMMUNOLOGY (2013)
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
Nicola Gagliani et al.
NATURE MEDICINE (2013)
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
E. L. Pearce et al.
SCIENCE (2013)
Indoleamine 2,3 dioxygenase and metabolic control of immune responses
David H. Munn et al.
TRENDS IN IMMUNOLOGY (2013)
Nitric oxide and cancer: a review
Sheetal Korde Choudhari et al.
WORLD JOURNAL OF SURGICAL ONCOLOGY (2013)
Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes
Rosula Garcia-Navas et al.
AUTOPHAGY (2012)
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
Xuguang Tai et al.
BLOOD (2012)
Chemotherapy broadens the range of tumor antigens seen by cytotoxic CD8+ T cells in vivo
Connie Jackaman et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)
Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
Seng-Ryong Woo et al.
CANCER RESEARCH (2012)
Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
Hang Li et al.
HEPATOLOGY (2012)
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
Gerritje J. W. van der Windt et al.
IMMUNITY (2012)
PGE2-Driven Induction and Maintenance of Cancer-Associated Myeloid-Derived Suppressor Cells
Natasa Obermajer et al.
IMMUNOLOGICAL INVESTIGATIONS (2012)
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
Anna N. Mendler et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury
Li Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
The TIGIT/CD226 Axis Regulates Human T Cell Function
Ester Lozano et al.
JOURNAL OF IMMUNOLOGY (2012)
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma
Michael A. Postow et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
Akio Ohta et al.
FRONTIERS IN IMMUNOLOGY (2012)
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Sophia Y. Lunt et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
Modulation of human T-cell functions by reactive nitrogen species
Tihana Kasic et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang et al.
IMMUNITY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek et al.
JOURNAL OF IMMUNOLOGY (2011)
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
Dimitrios Anastasiou et al.
SCIENCE (2011)
Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4
Omar S. Qureshi et al.
SCIENCE (2011)
CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
Xiaofeng Sun et al.
GASTROENTEROLOGY (2010)
Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
Rupal Ramakrishnan et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
Julien Fourcade et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
Kaori Sakuishi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites
Chiara Camisaschi et al.
JOURNAL OF IMMUNOLOGY (2010)
Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells
Valerie Dardalhon et al.
JOURNAL OF IMMUNOLOGY (2010)
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Erikka L. Carr et al.
JOURNAL OF IMMUNOLOGY (2010)
Lipid accumulation and dendritic cell dysfunction in cancer
Donna L. Herber et al.
NATURE MEDICINE (2010)
mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat
Nattida Chotechuang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
IDO inhibits T-cell function through suppressing Vav1 expression and activation
Runmei Li et al.
CANCER BIOLOGY & THERAPY (2009)
A Novel Cancer Therapy by Skin Delivery of Indoleamine 2,3-Dioxygenase siRNA
Meng-Chi Yen et al.
CLINICAL CANCER RESEARCH (2009)
CD226 Gly307Ser association with multiple autoimmune diseases
J. P. Hafler et al.
GENES AND IMMUNITY (2009)
The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
Greg M. Delgoffe et al.
IMMUNITY (2009)
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
Loise M. Francisco et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Anergic T Cells Are Metabolically Anergic
Yan Zheng et al.
JOURNAL OF IMMUNOLOGY (2009)
LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis
Creg J. Workman et al.
JOURNAL OF IMMUNOLOGY (2009)
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
NATURE (2009)
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
Xin Yu et al.
NATURE IMMUNOLOGY (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Cellular fatty acid uptake: a pathway under construction
Xiong Su et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2009)
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
Candace M. Cham et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways
Sarah R. Jacobs et al.
JOURNAL OF IMMUNOLOGY (2008)
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway
Hiroaki Shime et al.
JOURNAL OF IMMUNOLOGY (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
NATURE (2008)
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+T regulatory cells
Heather Kopf et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2007)
Molecular signature of CD8+ T cell exhaustion during chronic viral infection
E. John Wherry et al.
IMMUNITY (2007)
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor
Elke Valk et al.
IMMUNITY (2006)
Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
Divya Vats et al.
CELL METABOLISM (2006)
FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism
Milada Mahic et al.
JOURNAL OF IMMUNOLOGY (2006)
Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence
SD Chell et al.
CANCER RESEARCH (2006)
Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma.
MI Koukourakis et al.
CANCER RESEARCH (2006)
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
C Zhu et al.
NATURE IMMUNOLOGY (2005)
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
RV Parry et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells
F Baratelli et al.
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