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Bo Jiang et al.
TUMOR BIOLOGY (2016)
Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model
A. Gomez-Cadena et al.
CELL DEATH & DISEASE (2016)
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Chia-Wei Li et al.
NATURE COMMUNICATIONS (2016)
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
Shohei Koyama et al.
NATURE COMMUNICATIONS (2016)
Tumor microenvironment: Sanctuary of the devil
Lanlan Hui et al.
CANCER LETTERS (2015)
Multifunctional T Lymphocytes Generated After Therapy With an Antitumor Gallotanin-Rich Normalized Fraction Are Related to Primary Tumor Size Reduction in a Breast Cancer Model
Claudia Uruena et al.
INTEGRATIVE CANCER THERAPIES (2015)
Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases
Ali Roohbakhsh et al.
LIFE SCIENCES (2015)
On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update
Ana Laura Colin-Gonzalez et al.
NEUROCHEMISTRY INTERNATIONAL (2015)
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Marie Vetizou et al.
SCIENCE (2015)
Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, 0X40, GITR, CD27, CD28, and ICOS
Miguel F. Sanmamed et al.
SEMINARS IN ONCOLOGY (2015)
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells
Theodore Kouo et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Immunotherapy of Ovarian Cancer: The Role of Checkpoint Inhibitors
Francesca De Felice et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2015)
Beyond CTLA-4 and PD-1, the generation Z of negative checkpoint regulators
Isabelle Le Mercier et al.
FRONTIERS IN IMMUNOLOGY (2015)
S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro
Ya-si Xu et al.
ACTA PHARMACOLOGICA SINICA (2014)
The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8+ T Cell Effector Function
Robert J. Johnston et al.
CANCER CELL (2014)
TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells
Hongliang Fang et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2014)
Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy
Xiaozhou Fan et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
Bo Li et al.
NATURE (2014)
VISTA Is a Novel Broad-Spectrum Negative Checkpoint Regulator for Cancer Immunotherapy
J. Louise Lines et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
Chenfang Dong et al.
CANCER CELL (2013)
Elemene, One Ingredient of a Chinese Herb, Against Malignant Tumors: A Literature-based Meta-analysis
Hong-Bin Xu et al.
CANCER INVESTIGATION (2013)
Covalent lipid modifications of proteins
Marilyn D. Resh
CURRENT BIOLOGY (2013)
From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer
Helen Angel et al.
CURRENT OPINION IN IMMUNOLOGY (2013)
Toll-Like Receptor 4 Activity Protects Against Hepatocellular Tumorigenesis and Progression by Regulating Expression of DNA Repair Protein Ku70 in Mice
Ziyan Wang et al.
HEPATOLOGY (2013)
REGULATORY T-CELL MODULATION BY GREEN TEA IN CHRONIC LYMPHOCYTIC LEUKEMIA
G. D'Arena et al.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2013)
Therapeutic Potential of B and T Lymphocyte Attenuator Expressed on CD8+ T Cells for Contact Hypersensitivity
Daiki Nakagomi et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)
Polydatin: A review of pharmacology and pharmacokinetics
Qiao-Hui Du et al.
PHARMACEUTICAL BIOLOGY (2013)
B7 family checkpoint regulators in immune regulation and disease
Sabrina Ceeraz et al.
TRENDS IN IMMUNOLOGY (2013)
Ganoderma lucidum Extract Induces G1 Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells
Guosheng Wu et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2012)
Silibinin – A Promising New Treatment for Cancer
Catherine Wing Ying Cheung et al.
Anti-Cancer Agents in Medicinal Chemistry (2012)
Natural Products: Promising Resources for Cancer Drug Discovery
Susmita Mondal et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2012)
Berberine: New perspectives for old remedies
Micol Tillhon et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
Seng-Ryong Woo et al.
CANCER RESEARCH (2012)
Tim-3, a negative regulator of anti-tumor immunity
Ana Carrizosa Anderson
CURRENT OPINION IN IMMUNOLOGY (2012)
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
Tadashi Yokosuka et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression
Xin Gao et al.
PLOS ONE (2012)
Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action
Subhasree Ashok Nag et al.
FRONTIERS IN PHARMACOLOGY (2012)
Crosstalk between T Lymphocytes and Dendritic Cells
Claire Hivroz et al.
CRITICAL REVIEWS IN IMMUNOLOGY (2012)
The blockade of immune checkpoints in cancer immunotherapy
Drew M. Pardoll
NATURE REVIEWS CANCER (2012)
Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers
Christine Morand et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2011)
Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages
Zhongbin Deng et al.
BLOOD (2011)
Prospects for TIM3-Targeted Antitumor Immunotherapy
Shin Foong Ngiow et al.
CANCER RESEARCH (2011)
Anti-TIM3 Antibody Promotes T Cell IFN-γ-Mediated Antitumor Immunity and Suppresses Established Tumors
Shin Foong Ngiow et al.
CANCER RESEARCH (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
PD-L1 expression on tolerogenic APCs is controlled by STAT-3
Sabine J. Woelfle et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2011)
The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation
Marcos W. Steinberg et al.
IMMUNOLOGICAL REVIEWS (2011)
Low-dose curcumin leads to the inhibition of tumor growth via enhancing CTL-mediated antitumor immunity
Feifei Luo et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2011)
B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation
Hao Liu et al.
MOLECULAR CANCER THERAPEUTICS (2011)
The Accumulation and Prognosis Value of Tumor Infiltrating IL-17 Producing Cells in Esophageal Squamous Cell Carcinoma
Lin Lv et al.
PLOS ONE (2011)
Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker
Max Jan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Slow Down and Survive: Enigmatic Immunoregulation by BTLA and HVEM
Theresa L. Murphy et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)
ERK/p38 MAP-kinases and PI3K are involved in the differential regulation of B7-H1 expression in DC subsets
Svetlana Karakhanova et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2010)
TLRs and chronic inflammation
Caroline Ospelt et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
Putting the brakes on BTLA in T cell-mediated cancer immunotherapy
Chrystal M. Paulos et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion
Huan Yang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2010)
Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion
Xiaoyuan Huang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
Julien Fourcade et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
Kaori Sakuishi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
F. Stephen Hodi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Apigenin: A Promising Molecule for Cancer Prevention
Sanjeev Shukla et al.
PHARMACEUTICAL RESEARCH (2010)
High Expression of the Inhibitory Receptor BTLA in T-Follicular Helper Cells and in B-Cell Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia
Hasni M'Hidi et al.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2009)
COP9-Associated CSN5 Regulates Exosomal Protein Deubiquitination and Sorting
Yuelong Liu et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Sulforaphane Inhibits Prostate Carcinogenesis and Pulmonary Metastasis in TRAMP Mice in Association with Increased Cytotoxicity of Natural Killer Cells
Shivendra V. Singh et al.
CANCER RESEARCH (2009)
B7-H1 expression is regulated by MEK/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lymphoma
Ryo Yamamoto et al.
CANCER SCIENCE (2009)
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Trine H. Mogensen
CLINICAL MICROBIOLOGY REVIEWS (2009)
The basics of epithelial-mesenchymal transition
Raghu Kalluri et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Distribution and Biological Activities of the Flavonoid Luteolin
Miguel Lopez-Lazaro
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Pentacyclic Triterpene Distribution in Various Plants - Rich Sources for a New Group of Multi-Potent Plant Extracts
Sebastian Jaeger et al.
MOLECULES (2009)
PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
C. A. Crane et al.
ONCOGENE (2009)
Triptolide inhibits interferon-γ-induced programmed death-1-ligand 1 surface expression in breast cancer cells
Mei Liang et al.
CANCER LETTERS (2008)
Multitargeted therapy of cancer by silymarin
Kumaraguruparan Ramasamy et al.
CANCER LETTERS (2008)
TLR4 signaling promotes the expression of VEGF and TGF beta(1) in human prostate epithelial PC3 cells induced by lipopolysaccharide
Zengyang Pei et al.
CELLULAR IMMUNOLOGY (2008)
The role of TLR activation in inflammation
I. Sabroe et al.
JOURNAL OF PATHOLOGY (2008)
Anti-carcinogenic Effects of the Flavonoid Luteolin
Guenter Seelinger et al.
MOLECULES (2008)
CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
Guifang Cai et al.
NATURE IMMUNOLOGY (2008)
A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials
Yao-Zu Xiang et al.
PHYTOTHERAPY RESEARCH (2008)
Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine
Mohsen Imanshahidi et al.
PHYTOTHERAPY RESEARCH (2008)
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
Michal Marzec et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Combined coinhibitory and costimulatory modulation with Anti-BTLA and CTLA4Ig facilitates tolerance in murine islet allografts
W. Truong et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2007)
Negative and positive co-signaling with anti-BTLA (PJ196) and CTLA4Ig prolongs islet allograft survival
Wayne Truong et al.
TRANSPLANTATION (2007)
Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-γ and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
Jizhong Liu et al.
BLOOD (2007)
A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells
Xin Huang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest
Brent J. Yoder et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Silybin and silymarin - New and emerging applications in medicine
Radek Gazak et al.
CURRENT MEDICINAL CHEMISTRY (2007)
Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells
Mei-Hsien Lee et al.
PHYTOCHEMISTRY (2006)
TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer
MG Kelly et al.
CANCER RESEARCH (2006)
Beneficial effects of green tea -: A review
C Cabrera et al.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (2006)
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-γ-induced upregulation of B7-H1 (CD274)
SJ Lee et al.
FEBS LETTERS (2006)
CD8(+) T-cell memory in tumor immunology and immunotherapy
Christopher A. Klebanoff et al.
IMMUNOLOGICAL REVIEWS (2006)
Balancing co-stimulation and inhibition with BTLA and HVEM
Kenneth M. Murphy et al.
NATURE REVIEWS IMMUNOLOGY (2006)
Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells
M Kisielow et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator
JR Sedy et al.
NATURE IMMUNOLOGY (2005)
Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells
Y Fu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Murine B7-H3 is a negative regulator of T cells
DVR Prasad et al.
JOURNAL OF IMMUNOLOGY (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
TH Wang et al.
NATURE MEDICINE (2004)
An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection
P Han et al.
JOURNAL OF IMMUNOLOGY (2004)
Pharmacological effects of green tea on the gastrointestinal system
MWL Koo et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Toll-like receptor signaling
S Akira
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses
WK Suh et al.
NATURE IMMUNOLOGY (2003)
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
N Watanabe et al.
NATURE IMMUNOLOGY (2003)
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
Y Iwai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
CTLA-4: new insights into its biological function and use in tumor immunotherapy
JG Egen et al.
NATURE IMMUNOLOGY (2002)
Plant foods and herbal sources of resveratrol
J Burns et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2002)
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
L Monney et al.
NATURE (2002)
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
JG Egen et al.
IMMUNITY (2002)
Chemistry and pharmacology of the Citrus bioflavonoid hesperidin
A Garg et al.
PHYTOTHERAPY RESEARCH (2001)
Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium Wilfordii Hook F
BJ Chen
LEUKEMIA & LYMPHOMA (2001)
Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants
KH Miean et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)
B7-H3:: A costimulatory molecule for T cell activation and IFN-γ production
AI Chapoval et al.
NATURE IMMUNOLOGY (2001)
Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile
M Churchill et al.
JOURNAL OF SURGICAL RESEARCH (2000)