4.7 Article

Size-dependent transgenerational toxicity induced by nanoplastics in nematode Caenorhabditis elegans

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans

Huanliang Liu et al.

Summary: The study investigated the molecular basis of GLP-1 in controlling simulated microgravity stress in Caenorhabditis elegans, revealing that the activation of germline-intestine communication of insulin signaling by GLP-1 is essential for managing simulated microgravity toxicity.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Engineering, Environmental

Long-term nanoplastics exposure results in multi and trans-generational reproduction decline associated with germline toxicity and epigenetic regulation in Caenorhabditis elegans

Chan-Wei Yu et al.

Summary: The study reveals that long-term exposure to nanoplastics can lead to multi and transgenerational reproductive decline in Caenorhabditis elegans, potentially associated with germline toxicity and epigenetic regulation.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Toxicity of polystyrene nanoplastics in dragonfly larvae: An insight on how these pollutants can affect bentonic macroinvertebrates

Abraao Tiago Batista Guimaraes et al.

Summary: This study investigates the biochemical damage and neurotoxic effects of polystyrene nanoplastics on freshwater benthic macroinvertebrates, showing an increase in oxidative stress biomarkers and a potential impact on nerve and neuromuscular functions. The results suggest that even at low concentrations and short exposure times, PS NPs can affect the health of larvae, posing ecotoxicological risks for these organisms.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Multidisciplinary Sciences

Intestinal long non-coding RNAs in response to simulated microgravity stress in Caenorhabditis elegans

Lingmei Sun et al.

Summary: Long non-coding RNAs (lncRNAs) play important roles in regulating the response to environmental stresses in organisms. Using Caenorhabditis elegans as a model, this study identified specific intestinal lncRNAs involved in regulating the response to simulated microgravity stress, providing insights into the mechanisms by which lncRNAs impact organismal responses to environmental stressors.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Medicinal

Induction of Protective Response Associated with Expressional Alterations in Neuronal G Protein-Coupled Receptors in Polystyrene Nanoparticle Exposed Caenorhabditis elegans

Yunhan Yang et al.

Summary: The study investigated the role of expressional alterations in neuronal G protein-coupled receptors (GPCRs) in inducing a protective response to polystyrene nanoparticles (PS-NPs) in Caenorhabditis elegans. The findings suggest that specific GPCRs in neuronal cells regulate the toxicity of PS-NPs through different signaling pathways, providing important insights into the protective response mechanisms.

CHEMICAL RESEARCH IN TOXICOLOGY (2021)

Article Environmental Sciences

Intestinal mitochondrial unfolded protein response induced by nanoplastic particles in Caenorhabditis elegans

Huanliang Liu et al.

Summary: This study investigated the activation of intestinal mt UPR in Caenorhabditis elegans exposed to nanopolystyrene, highlighting the protective function of mt UPR activation against nanoplastic toxicity. The activation of mt UPR was found to be mediated by various signaling pathways, providing important insights into the molecular network involved in the protective response to nanoplastics at low concentrations.

CHEMOSPHERE (2021)

Article Environmental Sciences

Multigenerational effects of polyethylene terephthalate microfibers in Caenorhabditis elegans

Huanliang Liu et al.

Summary: The study found that continuous exposure to PET microfibers can have toxic effects on multiple generations of Caenorhabditis elegans, including impacting locomotion behavior, inducing reactive oxygen species production, reducing reproduction rates, and causing developmental abnormalities. Although some recovery was observed, significant decreases in body length and growth inhibition were evident in certain generations.

ENVIRONMENTAL RESEARCH (2021)

Article Environmental Sciences

Induction of protective response to polystyrene nanoparticles associated with methylation regulation in Caenorhabditis elegans

Shuting Wang et al.

Summary: The study revealed that exposure to polystyrene nanoparticles led to decreased expression of MET-2 in Caenorhabditis elegans, reflecting a protective response. This protective response was confirmed in both intestinal and germline cells. Furthermore, MET-2 was found to regulate the toxicity induction process of PS-NPs in intestinal cells and germline cells.

CHEMOSPHERE (2021)

Article Environmental Sciences

Induction of protective response to polystyrene nanoparticles associated with dysregulation of intestinal long non-coding RNAs in Caenorhabditis elegans

Yingyue Zhao et al.

Summary: Intestinal barrier in nematode Caenorhabditis elegans plays a crucial role in response to polystyrene nanoparticles (PS-NPs) by controlling specific long non-coding RNAs (lncRNAs). These lncRNAs regulate transcription factors to mediate a protective response to PS-NPs.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Dysregulated mir-76 mediated a protective response to nanopolystyrene by modulating heme homeostasis related molecular signaling in nematode Caenorhabditis elegans

Huanliang Liu et al.

Summary: Our study reveals that neuronal miRNA mir-76 controls nanoplastic toxicity in nematodes by regulating the globin protein GLB-10 in neurons. Moreover, we identified a signaling cascade involving HRG-7 and HRG-5 that is crucial for regulating heme homeostasis and NPS toxicity in organisms.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Review Engineering, Environmental

Microplastics and nanoplastics in the environment: Macroscopic transport and effects on creatures

Danlian Huang et al.

Summary: Plastic pollution is a major environmental issue globally, with current research mainly focusing on microplastics/nanoplastics in individual environments, neglecting the interconnected nature of the natural environment. The transport of microplastics/nanoplastics among different environments and their impact on organisms are crucial research areas that require urgent attention.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Comparison of transgenerational reproductive toxicity induced by pristine and amino modified nanoplastics in Caenorhabditis elegans

Lingmei Sun et al.

Summary: The study found that surface amino modification can enhance the transgenerational toxicity of nanoplastics, negatively impacting the reproductive capacity and gonad development of organisms. Amino modified nanoplastics showed more severe toxic effects on organisms compared to pristine nanopolystyrene.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Environmental Sciences

Alteration in expressions of ion channels in Caenorhabditis elegans exposed to polystyrene nanoparticles

Huanliang Liu et al.

Summary: Exposure to PS-NPs altered the expression of ion channel genes in Caenorhabditis elegans, leading to dysregulation of molecular networks in intestinal and neuronal cells, which mediated a protective response to PS-NPs in the worms.

CHEMOSPHERE (2021)

Article Environmental Sciences

Transgenerational neurotoxicity of polystyrene microplastics induced by oxidative stress in Caenorhabditis elegans

Haibo Chen et al.

Summary: This study found that maternal exposure to PS-MPs can result in the transgenerational neurotoxicity in C. elegans, with oxidative stress playing a key role in this process. Furthermore, the upregulation of oxidative stress-related genes across generations may be involved in regulating neurotoxicity in C. elegans.

CHEMOSPHERE (2021)

Article Environmental Sciences

Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans

Shuting Wang et al.

Summary: Neurotransmission related signals, specifically tyramine and glutamate, play crucial roles in regulating the toxicity of nanoplastics in Caenorhabditis elegans. Tyramine induces toxicity while glutamate alleviates toxicity, with both signals being mediated through neurons. Tyramine receptor TYRA-2 and glutamate receptors GLR-4 and GLR-8 act upstream of specific signaling pathways to regulate nanoplastic toxicity.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Engineering, Environmental

Acetylation regulation associated with the induction of protective response to polystyrene nanoparticles in Caenorhabditis elegans

Huanliang Liu et al.

Summary: Using Caenorhabditis elegans as a model, the study demonstrates that CBP-1 mediates protective response to polystyrene nanoparticles (PS-NPs) toxicity by regulating various signaling pathways in intestinal, neuronal, and germline cells.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Chemistry, Multidisciplinary

Response of G protein-coupled receptor CED-1 in germline to polystyrene nanoparticles in Caenorhabditis elegans

Yunhan Yang et al.

Summary: The study revealed that in Caenorhabditis elegans, the germline responds to NPS exposure through a signaling cascade mediated by GPCR CED-1, which may regulate NPS toxicity by affecting the activities of p38 MAPK and insulin signaling pathways in intestinal cells.

NANOSCALE ADVANCES (2021)

Article Engineering, Environmental

Surface-Related Toxicity of Polystyrene Beads to Nematodes and the Role of Food Availability

Marie-Theres Mueller et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2020)

Article Environmental Sciences

Effect of chronic exposure to nanopolystyrene on nematode Caenorhabditis elegans

Yuexiu Qiu et al.

CHEMOSPHERE (2020)

Review Environmental Sciences

Recent advances in toxicological research of nanoplastics in the environment: A review

Maocai Shen et al.

ENVIRONMENTAL POLLUTION (2019)

Review Environmental Sciences

Toxicological considerations of nano-sized plastics

P. A. Stapleton

AIMS ENVIRONMENTAL SCIENCE (2019)

Article Multidisciplinary Sciences

Production, use, and fate of all plastics ever made

Roland Geyer et al.

SCIENCE ADVANCES (2017)

Article Environmental Sciences

Characterisation of nanoplastics during the degradation of polystyrene

Scott Lambert et al.

CHEMOSPHERE (2016)

Letter Multidisciplinary Sciences

Microplastic exposure studies should be environmentally realistic

Robin Lenz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Engineering, Environmental

Multigenerational Study of Gold Nanoparticles in Caenorhabditis elegans: Transgenerational Effect of Maternal Exposure

Shin Woong Kim et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Review Toxicology

Caenorhabditis elegans:: An emerging model in biomedical and environmental toxicology

Maxwell C. K. Leung et al.

TOXICOLOGICAL SCIENCES (2008)