Journal
SCIENCE
Volume 374, Issue 6567, Pages 556-559Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abi8372
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Funding
- Wellcome Trust [107839/Z/15/Z, 107841/Z/15/Z]
- UK Dementia Research Institute [UK DRI-5004]
- Wellcome Trust [107839/Z/15/Z] Funding Source: Wellcome Trust
- MRC [UKDRI-5004] Funding Source: UKRI
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The common human experience shows that a long period without sleep is unsustainable and detrimental to health and behavior. Understanding the biochemical or circuit basis for the sleep drive could lead to the development of sedative drugs that can artificially stimulate the benefits of sleep.
Common human experience is that a long period without sleep is unsustainable, and it is also detrimental to health and behavior. The powerful and primal urge to sleep after sleep deprivation is intense and seems inescapable. The longer we stay awake, the more we feel the need to sleep, and however much we resist, we will inevitably succumb. Although it is obvious what benefits derive from other common and strong physiological drives, such as hunger, sex, and thirst, it is less obvious what drives us to sleep and what benefits accrue. Understanding the biochemical or circuit basis for the sleep drive could enable the benefits of sleep to be artificially stimulated with a new generation of sedative drugs.
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