Synthesis of Spiro[[1,2,5]oxadiazolo[3,4-b]pyrazine-5,2′-pyrroles] by Reaction of Pyrrolooxazinetriones with Diaminofurazan

The reaction of 8-aroyl-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,6,7-triones with 3,4-diaminofurazan afforded 3'-aroyl-4'-hydroxy-1'-(2-hydroxyethyl)-4H-spiro[[1,2,5]oxadiazolo[3,4-b]pyrazine-5,2'-pyrrole]-5',6(1'H,7H)-diones.

Automated summary

The reaction between 8-aroyl-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,6,7-triones and 3,4-diaminofurazan yields novel compounds with oxadiazole and pyrrole rings, along with aroyl and hydroxy substituents.