Journal
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
Volume 91, Issue 10, Pages 2086-2094Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070363221100261
Keywords
pyrimidine; sugar hydrazones; oxadiazole; thiazolopyrimidine; acyclic nucleosides; HepG2
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The new synthesized compounds have shown potential as anti-cancer candidates with high selective anti-cancer activity against liver cells without side effects on normal cells.
A group of new substituted pyrimidine compounds, and their thiazolopyrimidines and 1,3,4-oxadiazolyl acyclic sugar derivatives have been synthesized as potential anti-cancer candidates. Oxadiazolyl-pyrimidine hybrid compounds have been synthesized by the reaction of thioacetohydrazide derivative with carbon disulfide and heterocyclization of sugar hydrazones with acetic anhydride. The synthesized products have been studied for their anticancer activity against human liver carcinoma (HepG-2) and human normal retina pigmented epithelium (RPE-1). The synthesized sugar hydrazine of D-glucose, its 1,3,4-oxadiazole acyclic nucleoside and arylidine derivative demonstrate high selective anti-cancer activity against liver cell line without side effects on normal cells.
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