4.1 Article

Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

Shubham Khot et al.

Summary: 1,4-dihydropyridine is a versatile heterocyclic ring system with diverse pharmacological activities, utilized for treating cardiovascular diseases and other conditions.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

Review Neurosciences

From Hybrids to New Scaffolds: The Latest Medicinal Chemistry Goals in Multi-target Directed Ligands for Alzheimer's Disease

Jazmin Alarcon-Esposito et al.

Summary: Alzheimer's disease is a common cause of cognitive decline in elderly individuals, with complex and multifactorial etiology. The traditional one drug-one target paradigm is not effective for AD and other complex disorders, highlighting the potential of the multitarget approach in treatment.

CURRENT NEUROPHARMACOLOGY (2021)

Article Anesthesiology

Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain

Anna Piotrowska et al.

Summary: The study identifies the pronociceptive effects of nonopioid peptides derived from opioid prohormones in neuropathic pain and proposes a pharmacological approach to restore the balance of endogenous opioid systems. The bifunctional hybrids OP-linker-MC4 show promise as important prototypes of drugs for neuropathic pain treatment, with potent and long-lasting antinociceptive effects and delayed development of tolerance compared to morphine.
Review Chemistry, Medicinal

Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance

Harish C. Upadhyay

Summary: The widespread use of antibiotics has led to bacterial resistance and recurrent infections. To overcome this issue, multidrug therapy or single drugs acting on multiple targets may be utilized. Natural product-based hybrid molecules may provide a super alternative to combat drug resistance caused by various bacterial and fungal strains.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Synthesis and Analgesic Activity of New Heterocyclic Cyanothioacetamide Derivatives

I. V. Bibik et al.

Summary: The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation yields heterocyclic derivatives with analgesic activity, some of which show superior antinociceptive effect compared to ketorolac.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2021)

Review Chemistry, Medicinal

The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

Yong Ling et al.

Summary: Pyridine-based ring systems are extensively used in drug design, with many therapeutic agents derived from pyridine or dihydropyridine approved for various diseases. The prospects of more drugs containing these two heterocycles in the future look promising, as they continue to play an expanding role in medicinal chemistry and drug development.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Biochemistry & Molecular Biology

Antinociceptive Efficacy of the μ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking

Maria Dumitrascuta et al.

Summary: The mixed MOR/NOP receptor peptide KGNOP1 demonstrates potent and effective analgesic effects in mouse models of pain, particularly in inflammatory pain. Compared to morphine, KGNOP1 shows reduced adverse effects and holds promise for the development of new analgesics with fewer side effects related to MOR, such as abuse and dependence.

MOLECULES (2021)

Article Chemistry, Multidisciplinary

New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity

D. S. Krivokolysko et al.

Summary: A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments were synthesized by reacting cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. Some of the resulting compounds demonstrated an antinociceptive effect, superior to that of the reference drug.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2021)

Review Chemistry, Organic

para-Aminobenzoic Acid-A Substrate of Immense Significance

Zaib Un Nisa et al.

MINI-REVIEWS IN ORGANIC CHEMISTRY (2020)

Article Chemistry, Medicinal

GalaxySagittarius: Structure- and Similarity-Based Prediction of Protein Targets for Druglike Compounds

Jinsol Yang et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)

Review Chemistry, Medicinal

Hybrid molecules based on 1,3,5-triazine as potential therapeutics: A focused review

Parteek Prasher et al.

DRUG DEVELOPMENT RESEARCH (2020)

Article Biochemical Research Methods

Webina: an open-source library and web app that runs AutoDock Vina entirely in the web browser

Yuri Kochnev et al.

BIOINFORMATICS (2020)

Review Chemistry, Physical

Recent Approaches to Chiral 1,4-Dihydropyridines and their Fused Analogues

Martins Rucins et al.

CATALYSTS (2020)

Article Chemistry, Multidisciplinary

Recent advances in the chemistry of thieno[2,3-b]pyridines 1. Methods of synthesis of thieno[2,3-b]pyridines

V. V. Dotsenko et al.

RUSSIAN CHEMICAL BULLETIN (2020)

Article Biotechnology & Applied Microbiology

Analgesic activity of some aroylhydrazone-based molecular hybrids with antiseizure activity: in vivo and in silico evaluations

Stanislav Marchev et al.

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2019)

Article Chemistry, Medicinal

Harnessing Polypharmacology with Medicinal Chemistry

Maria Laura Bolognesi

ACS MEDICINAL CHEMISTRY LETTERS (2019)

Review Chemistry, Medicinal

1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects

Abhinav Prasoon Mishra et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

Viktoriya Ivasiv et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

Review Pharmacology & Pharmacy

Developments with multi-target drugs for Alzheimer's disease: an overview of the current discovery approaches

Juan F. Gonzalez et al.

EXPERT OPINION ON DRUG DISCOVERY (2019)

Review Chemistry, Medicinal

Hybrid Molecules Development: A Versatile Landscape for the Control of Aritifungal Drug Resistance: A Review

Chioma G. Anusionwu et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Synthesis and Pharmacological Evaluation of Hybrids Targeting Opioid and Neurokinin Receptors

Karol Wtorek et al.

MOLECULES (2019)

Review Pharmacology & Pharmacy

Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery

Balaguru Ravikumar et al.

EXPERT OPINION ON DRUG DISCOVERY (2018)

Article Gastroenterology & Hepatology

Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon

I. Kaji et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2018)

Review Chemistry, Organic

A Review: Synthesis and Medicinal Importance of Nicotinonitriles and Their Analogous

Moustafa A. Gouda et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2018)

Review Chemistry, Organic

Overview on the synthetic routes to nicotine nitriles

M. A. Salem et al.

SYNTHETIC COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

BCL-2 family proteins: changing partners in the dance towards death

Justin Kale et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Pharmacology & Pharmacy

Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System

Tilo Grosser et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2017)

Review Chemistry, Medicinal

Hybrid molecules: The privileged scaffolds for various pharmaceuticals

Shaveta et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

From hybrid compounds to targeted drug delivery in antimalarial therapy

Rudi Oliveira et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators

Atul D. Jain et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Pharmacology & Pharmacy

Hantzsch-Type Dihydropyridines and Biginelli-Type Tetrahydropyrimidines: A Review of their Chemotherapeutic Activities

Saghi Sepehri et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2015)

Article Chemistry, Organic

Synthesis of New 1, 10-Phenanthroline Analogs as Potent Antimicrobial Agents Using Montmorillonite K-10 as Catalyst

Ramakanth Pagadala et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

David Gfeller et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Chemistry, Organic

CHEMISTRY OF 2-AMINO-3-CYANOPYRIDINES

Moustafa A. Gouda et al.

SYNTHETIC COMMUNICATIONS (2014)

Article Pharmacology & Pharmacy

Complex Pharmacology of Novel Allosteric Free Fatty Acid 3 Receptor Ligands

Brian D. Hudson et al.

MOLECULAR PHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

Autotaxin inhibition: Development and application of computational tools to identify site-selective lead compounds

Derek D. Norman et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2013)

Article Chemistry, Organic

Synthesis and Alkylation of N-Methylmorpholinium 4-Aryl-3-cyano-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-selenolates

K. A. Frolov et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2013)

Article Chemistry, Medicinal

Inhibitors of Tick-Borne Flavivirus Reproduction from Structure-Based Virtual Screening

Dmitry I. Osolodkin et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Article Chemistry, Medicinal

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

Feixiong Cheng et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Medicinal

A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design

Marijn P. A. Sanders et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

GalaxyWEB server for protein structure prediction and refinement

Junsu Ko et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Biochemistry & Molecular Biology

Privileged scaffolds for library design and drug discovery

Matthew E. Welsch et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2010)

Article Pharmacology & Pharmacy

TRIOXAQUINES: HYBRID MOLECULES FOR THE TREATMENT OF MALARIA

Shikha S. Chauhan et al.

DRUG NEWS & PERSPECTIVES (2010)

Review Pharmacology & Pharmacy

Dihydropyridines: evaluation of their current and future pharmacological applications

Najmeh Edraki et al.

DRUG DISCOVERY TODAY (2009)

Review Biotechnology & Applied Microbiology

BCL-2 family antagonists for cancer therapy

Guillaume Lessene et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Review Pharmacology & Pharmacy

Cyclooxygenase enzymes: Regulation and function

FA Fitzpatrick

CURRENT PHARMACEUTICAL DESIGN (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Review Chemistry, Medicinal

The 1,4-Dihydropyridine Nucleus: A Pharmacophoric Template Part 1. Actions at Ion Channels

David J. Triggle

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2003)

Review Biochemistry & Molecular Biology

Drug evolution: p-aminobenzoic acid as a building block

A Kluczyk et al.

CURRENT MEDICINAL CHEMISTRY (2002)