Journal
RHEUMATOLOGY INTERNATIONAL
Volume 42, Issue 7, Pages 1187-1196Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-021-05023-x
Keywords
Choroidal thickness; Choroidal vascularity index; Juvenile idiopathic arthritis; Luminal area; Stromal area; Uveitis
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The study aimed to evaluate the retina and choroid in children with juvenile idiopathic arthritis (JIA) using optical coherence tomography (OCT). The choroid was found to be thicker in JIA patients compared to healthy controls, possibly indicating subclinical choroidal inflammation. Ophthalmologic examination, including choroidal imaging, in a larger cohort may help clarify this aspect.
We aimed to evaluate the retina and the choroid in children with juvenile idiopathic arthritis (JIA) employing optical coherence tomography (OCT). This cross-sectional study, carried out between June 2017-December 2019, included JIA patients with (JIAU; n = 28) and without (JIAN; n = 65) uveitis and age-matched healthy controls (HC) (n = 102). Laboratory and demographic information of the children were obtained from hospital records. Activity of the disease was evaluated by the Juvenile Arthritis Disease Activity Score-71 (JADAS-71). Choroidal scans were obtained with spectral domain-OCT in enhanced-depth imaging (EDI)-OCT mode to assess choroidal thickness (ChT) at five locations (under the fovea, at 750 and 1500 mu m nasal and temporal sections), luminal area (LA), stromal area (SA), total subfoveal choroidal area (TCA) and CVI (choroidal vascularity index). Central foveal thickness (CFT) and 1-mm diameter foveal thickness (FT) were calculated automatically through macular volume scan analysis. The choroid was significantly thicker in JIAU and JIAN patients than in HC at the subfoveal and at the 750N, 750T, 1500T points (p < 0.001, p = 0.009, p < 0.001, and p < 0.001, respectively). The CVI was lower in JIAU patients than in JIAN patients and HC (p = 0.02). Conversely, CFT was greater in JIAU patients as compared to the JIAN patients and HC (p = 0.02). Changes in chorioretinal OCT parameters in the absence of uveitis in JIA patients may reflect subclinical choroidal inflammation in these patients. Ophthalmologic examination, including choroidal imaging in a larger cohort, may clarify this aspect.
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