From B-cell self-control to therapeutic approaches, could B-cell intrinsic strategies temper IgE responses and IgE memory

Persisting adaptive humoral immunity relies on two key cell types: memory B lymphocytes and long-lived plasma cells. Independently from the specific Ig class they produce, those cells can on one side maintain immunity but on the other side account for dysimmune conditions or hypersensitivity. Strin-gent control is thus required for both their generation and their survival. Among Ig classes, IgE carries the most powerful pro-inflammatory properties, even at minimal concentration. IgE responses and memory, although protecting against parasites and certain venoms, can inversely mediate devastating effects. The long-term memory of anaphylactic responses against allergens thus stands as the black side of IgE responses, accounting for chronic conditions punctuated with dramatic acute adverse events, some even-tually lethal. To manage both their value and their danger, the immune system has evolved with multiple and drastic safeguards around IgE responses, notably ensuring a B-cell self control which could now be exploited and reinforced by new specific therapeutic strategies. (c) 2021 Elsevier Masson SAS. All rights reserved.

Automated summary

Persisting adaptive humoral immunity relies on memory B lymphocytes and long-lived plasma cells. IgE responses, although protective against parasites and certain venoms, can have detrimental effects and result in chronic conditions with dramatic acute adverse events.