Journal
INSECT MOLECULAR BIOLOGY
Volume 26, Issue 2, Pages 127-139Publisher
WILEY
DOI: 10.1111/imb.12282
Keywords
systemic RNAi response; nanotechnology and vector control; dsRNA delivery systems in mosquitoes
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RNA interference (RNAi) refers to the process of post-transcriptional silencing of cellular mRNA by the application of double-stranded RNA (dsRNA). RNAi strategies have been widely employed to regulate gene expression in plants and animals including insects. With the availability of the full genome sequences of major vector mosquitoes, RNAi has been increasingly used to conduct genetic studies of human pathogens in mosquito vectors and to study the evolution of insecticide resistance in mosquitoes. This review summarizes the recent progress in our understanding of mosquito-pathogen interactions using RNAi and various methods of dsRNA delivery in mosquitoes at different stages. We also discuss potential applications of this technology to develop novel tools for vector control.
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