Journal
REVIEWS IN CARDIOVASCULAR MEDICINE
Volume 23, Issue 2, Pages -Publisher
IMR PRESS
DOI: 10.31083/j.rcm2302063
Keywords
Neuregulin-1; acute myocardial infarction; biomarker; left ventricular function
Categories
Funding
- Ludwig Boltzmann Institute for Cardiovascular Research
- Austria-Hungary Action Foundation [92ou8]
- Association for Research on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)
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The level of NRG-1 is affected in patients with acute myocardial infarction (MI). Further large clinical trials are needed to confirm this hypothesis.
Background: Neuregulin-1 (NRG-1) is a stress-mediated transmembrane growth factor. Reduced myocardial damage and higher NRG1 levels upon treatment with remote ischemic conditioning (RIC) has been described in rats. However, the role of NRG-1 in patients with acute myocardial infarction (MI) is unknown. Thus, we conducted a post hoc analysis of a randomized controlled trial that tested RIC in patients with MI scheduled for primary percutaneous coronary intervention (PCI). Methods: Blood was drawn from 30 patients before RIC/PCI, within 1 hour, 4 days and 1 month later. Median left ventricular ejection fraction (LVEF) in the overall study population following MI was 48.5%. Results: NRG-1 plasma levels decreased significantly following PCI/RIC and remained decreased up to 1 month following MI (p < 0.0001). We observed no association of NRG-1 with other variables, including total ischemic time, LVEF or RIC. Conclusions: Thus, we identified NRG-1 may be independently affected by MI. However, further large clinical trials are warranted to clarify this hypothesis.
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