Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 48, Issue 4, Pages 1515-1540Publisher
SPRINGER
DOI: 10.1007/s11164-021-04643-z
Keywords
Cyclocondensation reaction; Decahydroacridine-1,8-diones; beta-Enaminone; Multi-component reaction; Polyhydroquinolines
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Funding
- Research Council
- Office of Graduate Studies of the University of Isfahan
- Ministry of Higher Education of Iran
- University of Hormozgan
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Various symmetric and asymmetric decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The step-wise addition of reactants in this method avoids the formation of undesired by-products, leading to a cleaner work up of the reaction.
Various symmetrical and unsymmetrical decahydroacridine-1,8-dione and polyhydroquinoline derivatives were synthesized via two-step cyclocondensation reactions. The advantages of this step-wise addition of reactants in comparison with other one-pot reactions are avoiding the formation of 2 or 3 undesired by-products, therefore allowing cleaner work up of reaction. The important factor of this effective cyclocondensation method is that the prepared beta-enaminone component was added dropwise to the solution, in which the Knoevenagel condensation product is slowly being formed by reaction of aldehyde molecule and 1,3-dicarbonyl compounds. The results of the proposed step-wise method are compared and discussed with those obtained in the one-pot reactions.
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