Journal
INORGANICA CHIMICA ACTA
Volume 441, Issue -, Pages 20-33Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2015.10.041
Keywords
Hmbt; Platinum; Anticancer; DNA; Complexes
Categories
Funding
- Ministry of Higher Education in Egypt
- NSERC (Canada) Discovery grant
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The synthesis of new complexes of 2-mercaptobenzothiazole (Hmbt), [Zn(L)(mbt)(H2O)(2)]Cl, [M(mbt)(L)]Cl (M(II) = Pd, Pt; L = bpy, phen), [M(mbt)(PPh3)Cl] (M(II) = Pd, Pt), [Zn(PPh3)(2)(Hmbt)(2)Cl-2], [Ru (mbt)(2)(H2O)(2)], [Ru(PPh3)(2)(mbt)(2)], [Ir(mbt)(3)]Cl, [OsO2(mbt)(2)], [Rh(mbt)(3)(H2O)(3)], [Ag(Hmbt)(mbt)] and [Au(mbt)(2)Cl], are reported. Their structures are discussed on the bases of spectroscopic [(IR, Raman, UV-Vis, NMR (H-1, C-13 and P-31)and mass)], elemental analysis, molar conductivity and thermal degradation measurements. The in vitro anticancer activity of Hmbt and its complexes, [Zn(L)(mbt)(H2O)(2)]Cl, [M (L)(Hmbt)]Cl (M(II) = Pd, Pt; L = bpy, phen)and [Ag(Hmbt)(mbt)], were evaluated against human breast cancer (MDA-MB231)and human ovarian cancer (OVCAR-8)cell lines. The CT-DNA-binding properties of [Zn(mbt)(phen)(H2O)(2)] Cl, [Pd(Hmbt)(phen)]Cl, [Pt(L)(Hmbt)]Cl (L = bpy, phen)and [Au(mbt)(2)Cl], were studied using circular dichroism (CD)spectroscopy. The CD spectral data are further supported by UV-Vis titrations of [Pt(phen)(mbt)]Cl, [Pd(phen)(mbt)]Cl and [Zn(mbt)(phen)(H2O)(2)]Cl with CT-DNA. The results indicate that the complexes may have intercalative CT-DNA binding capabilities. (C) 2015 Elsevier B.V. All rights reserved.
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