Journal
RECORDS OF NATURAL PRODUCTS
Volume 16, Issue 4, Pages 324-334Publisher
ACG PUBLICATIONS
DOI: 10.25135/rnp.287.2107.2127
Keywords
Aconitum carmichaelii; monoester-type C-19-diterpenoid alkaloids; H9c2 cells; zebrafish embryos
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Funding
- National Natural Science Foundation of China (NNSFC) [81630101, 81891012, 81891010]
- Sichuan Science and Technology Program [2018JZ0081]
- Xinglin Scholar Plan of Chengdu University of Traditional Chinese Medicine [YXRC2018005, BSH2019028, QNXZ2019030]
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A new monoester-type C19-diterpenoid alkaloid, along with six known compounds, were isolated from the lateral roots of Aconitum carmichaelii Debx. The compounds exhibited cardiotoxicity, with compound 6 being the most toxic.
A new (1) and six known (2-7) monoester-type C19-diterpenoid alkaloids were isolated from the lateral roots of Aconitum carmichaelii Debx. Their structures were determined by spectroscopic techniques and calculations of NMR chemical shifts. Compound 1 (1-epi-hokbusine A) was an aconitine-type diterpenoid alkaloid possessing an unusual 1 beta-methoxy group. According to the main toxicity of the lateral roots of A. carmichaelii, the cardiotoxic effects of the isolates were evaluated using H9c2 rat myocardial cells and zebrafish embryos. The results showed that all the monoester-type C19-diterpenoid alkaloids exhibited cardiotoxicity, and compound 6 was found to be the most toxic compound.
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