Pickering emulsions-chitosan hydrogel beads carrier system for loading of resveratrol: Formulation approach and characterization studies

The present study aimed to the evaluation of novel resveratrol (RSV)-loaded Pickering emulsions-chitosan hydrogel beads that were prepared using an injection-gelation method drug-delivery system for topical application of RSV. The effect of encapsulation on the properties of RSV-loaded Pickering emulsions was investigated using dynamic light scattering (DLS), Scanning electron microscope (SEM), X-ray diffraction (XRD), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). The 48 days storage study indicated that Pickering emulsions-chitosan hydrogel beads possessed excellent physical stability, while the antioxidant properties of RSV were not affected. Besides, there was no significant cytotoxicity of Pickering emulsion-chitosan hydrogel beads on L929 cells and sustained RSV release within 12 h. In vitro permeation studies demonstrated that Pickering emulsion-chitosan hydrogel beads could significantly enhance RSV accumulation during dermal applications. The overall results suggested that the Pickering emulsions-chitosan hydrogel beads might be a suitable carrier for RSV topical applications.

Automated summary

The study evaluated a novel resveratrol carrier with excellent physical stability and antioxidant properties, no cytotoxicity to cells, sustained release of resveratrol within 12 hours, and significantly enhanced resveratrol accumulation during dermal applications.