4.3 Review

Mechanisms of ATP release in pain: role of pannexin and connexin channels

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Nociceptive signaling of P2X receptors in chronic pain states

Kazuhide Inoue

Summary: P2X3Rs, P2X2/3Rs, and P2X4Rs play important roles in neuropathic pain, with P2X4Rs in spinal microglia being particularly significant for drug development. Recent studies have developed novel antagonists for P2X4Rs, with promising results in clinical trials demonstrating their safety and efficacy.

PURINERGIC SIGNALLING (2021)

Review Biochemistry & Molecular Biology

Geoffery Burnstock's influence on the evolution of P2X3 receptor pharmacology

Michael F. Jarvis

PURINERGIC SIGNALLING (2021)

Article Cardiac & Cardiovascular Systems

Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood

Brett S. Kirby et al.

Summary: The study found that Panx1 channels participate in hypoxic vasodilation by regulating hypoxia-sensitive extracellular ATP levels in blood. Mice lacking Panx1 showed attenuated decrease in blood pressure and reduced increase in limb blood flow during hypoxia, along with lower plasma ATP levels. This indicates the important role of Panx1 in vascular responses to hypoxia.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Article Multidisciplinary Sciences

Pannexin 3 regulates skin development via Epiprofin

Peipei Zhang et al.

Summary: Panx3 regulates skin development by modulating the transcription factor Epfn. Panx3(-/-) mice show impaired skin development and delayed hair follicle regeneration, while Panx3 overexpression promotes HaCaT cell differentiation.

SCIENTIFIC REPORTS (2021)

Article Biology

ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

Adishesh K. Narahari et al.

Summary: The study demonstrated that Panx1 channels activated by caspase allow large molecule permeation, including anionic and large-molecule permeants, while also allowing large cationic molecules to permeate at a slower rate. Additionally, Panx1 channels provide a pathway for the flux of ATP and other signaling metabolites, both anionic (glutamate) and cationic (spermidine).

ELIFE (2021)

Review Biochemistry & Molecular Biology

Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review

Nurul Ajilah Mohamed Khir et al.

Summary: The P2X4 receptor plays a significant role in the nervous system and has been implicated in the transmission of pain associated with rheumatoid arthritis.

PURINERGIC SIGNALLING (2021)

Article Physiology

Structure versus function: Are new conformations of pannexin 1 yet to be resolved?

Carsten Mim et al.

Summary: Panx1 plays a crucial role in various physiological and pathological contexts, functioning as a transmembrane pathway for ATP and a highly selective membrane channel for chloride ions.

JOURNAL OF GENERAL PHYSIOLOGY (2021)

Editorial Material Pharmacology & Pharmacy

Adenosine Metabotropic Receptors in Chronic Pain Management

Livio Luongo et al.

FRONTIERS IN PHARMACOLOGY (2021)

Letter Cell Biology

Cryo-EM structure of human heptameric Pannexin 1 channel

Ronggui Qu et al.

CELL RESEARCH (2020)

Article Chemistry, Medicinal

P2Y14 Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

Fatma Mufti et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

Review Anesthesiology

Treatment of chronic neuropathic pain: purine receptor modulation

Kenneth A. Jacobson et al.

Article Cell Biology

Mechanisms of hearing loss and cell death in the cochlea of connexin mutan mice

Bei Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Physiopathological roles of vesicular nucleotide transporter (VNUT), an essential component for vesicular ATP release

Nao Hasuzawa et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

Article Multidisciplinary Sciences

Structures of human pannexin 1 reveal ion pathways and mechanism of gating

Zheng Ruan et al.

NATURE (2020)

Review Neurosciences

Emerging importance of satellite glia in nervous system function and dysfunction

Menachem Hanani et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Article Biochemistry & Molecular Biology

P2X3 receptors contribute to transition from acute to chronic muscle pain

Carolina Ocanha Jorge et al.

PURINERGIC SIGNALLING (2020)

Review Biochemistry & Molecular Biology

P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases

Peter Illes

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Neurosciences

Gap junctions, pannexins and pain

David C. Spray et al.

NEUROSCIENCE LETTERS (2019)

Review Neurosciences

Connexin Hemichannels in Astrocytes: Role in CNS Disorders

LingYan Xing et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Review Pharmacology & Pharmacy

Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics

Norimitsu Morioka et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

Review Neurosciences

Astrocytes in chronic pain and itch

Ru-Rong Ji et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Article Pharmacology & Pharmacy

Microglia-Mediated Regulation of Neuropathic Pain: Molecular and Cellular Mechanisms

Makoto Tsuda

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

Article Biochemistry & Molecular Biology

The Inhibition by Guanfu Base A of Neuropathic Pain Mediated by P2Y12 Receptor in Dorsal Root Ganglia

Lifang Zou et al.

ACS CHEMICAL NEUROSCIENCE (2019)

Review Physiology

Revisiting multimodal activation and channel properties of Pannexin 1

Yu-Hsin Chiu et al.

JOURNAL OF GENERAL PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Vesicular nucleotide transporter mediates ATP release and migration in neutrophils

Yuika Harada et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Medicine, General & Internal

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

Manao Kinoshita et al.

EBIOMEDICINE (2018)

Article Medicine, Research & Experimental

Dexmedetomidine Attenuates Neuropathic Pain by Inhibiting P2X7R Expression and ERK Phosphorylation in Rats

Jia-Piao Lin et al.

EXPERIMENTAL NEUROBIOLOGY (2018)

Article Dentistry, Oral Surgery & Medicine

Connexin 43 expression in satellite glial cells contributes to ectopic tooth-pulp pain

Hiroki Komiya et al.

JOURNAL OF ORAL SCIENCE (2018)

Article Biochemistry & Molecular Biology

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

Nicole E. Burma et al.

NATURE MEDICINE (2017)

Review Clinical Neurology

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

Stephen D. Skaper et al.

NEUROSCIENTIST (2017)

Article Multidisciplinary Sciences

Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain

Yuri Kato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Neurosciences

Mast cells in neuropathic pain: an increasing spectrum of their involvement in pathophysiology

Gunjanpreet Kaur et al.

REVIEWS IN THE NEUROSCIENCES (2017)

Article Neurosciences

Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?

Mauricio A. Retamal et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Review Pharmacology & Pharmacy

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology

Leanne Stokes et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Multidisciplinary Sciences

P2X3 receptor involvement in endometriosis pain via ERK signaling pathway

Shaojie Ding et al.

PLOS ONE (2017)

Article Immunology

Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain

Benjamin Luchting et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Article Medicine, General & Internal

Central Neuropathic Pain Syndromes

James C. Watson et al.

MAYO CLINIC PROCEEDINGS (2016)

Article Neurosciences

Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity

Nicholas L. Weilinger et al.

NATURE NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Takahiro Masuda et al.

NATURE COMMUNICATIONS (2016)

Review Neurosciences

Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions

Rosario Gajardo-Gomez et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Yuta Matsumura et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain

Regina Hanstein et al.

SCIENTIFIC REPORTS (2016)

Article Oncology

Oxaliplatin enhances gap junction-mediated coupling in cell cultures of mouse trigeminal ganglia

Jeppe Norgaard Poulsen et al.

EXPERIMENTAL CELL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development

Yuhao Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Macrophage-T Cell Interactions Mediate Neuropathic Pain through the Glucocorticoid-induced Tumor Necrosis Factor Ligand System

Yuka Kobayashi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Biology

ATP release through pannexon channels

Gerhard Dahl

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Article Endocrinology & Metabolism

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Samantha E. Adamson et al.

MOLECULAR METABOLISM (2015)

Review Clinical Neurology

Spinal Gap Junction Channels in Neuropathic Pain

Young Hoon Jeon et al.

KOREAN JOURNAL OF PAIN (2015)

Review Biochemistry & Molecular Biology

Pannexin channels and their links to human disease

Silvia Penuela et al.

BIOCHEMICAL JOURNAL (2014)

Review Biochemistry & Molecular Biology

Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities

Gennady G. Yegutkin

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

Article Biochemistry & Molecular Biology

SLC17A9 Protein Functions as a Lysosomal ATP Transporter and Regulates Cell Viability

Qi Cao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Pannexin 1 and Pannexin 3 Channels Regulate Skeletal Muscle Myoblast Proliferation and Differentiation

Stephanie Langlois et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Clinical Neurology

The International Spinal Cord Injury Pain Basic Data Set ( version 2.0)

E. Widerstroem-Noga et al.

SPINAL CORD (2014)

Article Multidisciplinary Sciences

Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission

Youichi Shinozaki et al.

SCIENTIFIC REPORTS (2014)

Review Physiology

The pannexins: past and present

Stephen R. Bond et al.

FRONTIERS IN PHYSIOLOGY (2014)

Review Cell Biology

TRP Channels and Pain

David Julius

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 29 (2013)

Article Neurosciences

Purinergic transmission and transglial signaling between neuron somata in the dorsal root ganglion

Gabriela M. Rozanski et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2013)

Review Medicine, Research & Experimental

Contribution of macrophages to peripheral neuropathic pain pathogenesis

Violeta Ristoiu

LIFE SCIENCES (2013)

Article Multidisciplinary Sciences

Air-Stimulated ATP Release from Keratinocytes Occurs through Connexin Hemichannels

Travis P. Barr et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

Hulya Karatas et al.

SCIENCE (2013)

Review Neurosciences

Pannexin: From discovery to bedside in 11±4 years?

Gerhard Dahl et al.

BRAIN RESEARCH (2012)

Article Neurosciences

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

Sylvia O. Suadicani et al.

Article Neurosciences

Critical Role of Connexin 43 in Secondary Expansion of Traumatic Spinal Cord Injury

Chunlan Huang et al.

JOURNAL OF NEUROSCIENCE (2012)

Editorial Material Biochemistry & Molecular Biology

Pannexin channels are not gap junction hemichannels

Gina E. Sosinsky et al.

CHANNELS (2011)

Article Cardiac & Cardiovascular Systems

Pannexin1 Regulates α1-Adrenergic Receptor-Mediated Vasoconstriction

Marie Billaud et al.

CIRCULATION RESEARCH (2011)

Article Biochemistry & Molecular Biology

Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

Lucia Seminario-Vidal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Editorial Material Anesthesiology

A new definition of neuropathic pain

Troels S. Jensen et al.

Article Multidisciplinary Sciences

The Astrocyte-Targeted Therapy by Bushi for the Neuropathic Pain in Mice

Keisuke Shibata et al.

PLOS ONE (2011)

Article Pharmacology & Pharmacy

Spinal Astrocytes as Therapeutic Targets for Pathological Pain

Takayuki Nakagawa et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2010)

Editorial Material Rheumatology

PAIN How macrophages mediate inflammatory pain via ATP signaling

Per-Johan Jakobsson

NATURE REVIEWS RHEUMATOLOGY (2010)

Review Clinical Neurology

Targeting Astrocyte Signaling for Chronic Pain

Yong-Jing Gao et al.

NEUROTHERAPEUTICS (2010)

Review Cell Biology

Connexins: a myriad of functions extending beyond assembly of gap junction channels

Hashem A. Dbouk et al.

CELL COMMUNICATION AND SIGNALING (2009)

Review Neurosciences

Microglia and Neuropathic Pain

Kazuhide Inoue et al.

Review Immunology

Molecular basis of neuroimmune interaction in an in vitro coculture approach

Mamoru Nakanishi et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2008)

Article Neurosciences

P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury

Hidetoshi Tozaki-Saitoh et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

Michael Cronin et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2008)

Review Anesthesiology

The Kyoto protocol of IASP Basic Pain Terminology

John D. Loeser et al.

Article Multidisciplinary Sciences

ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear

Fabio Anselmi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane

Daniela Boassa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Multidisciplinary Sciences

Mechanisms of sensory transduction in the skin

Ellen A. Lumpkin et al.

NATURE (2007)

Article Cardiac & Cardiovascular Systems

Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction

Brant E. Isakson et al.

CIRCULATION RESEARCH (2007)

Review Physiology

Physiology and pathophysiology of purinergic neurotransmission

Geoffrey Burnstock

PHYSIOLOGICAL REVIEWS (2007)

Review Pharmacology & Pharmacy

Liaisons dangereuses: P2X(7) and the inflammasome

Francesco Di Virgilio

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Review Neurosciences

Astrocyte calcium waves: What they are and what they do

Eluna Scemes et al.

Review Biochemistry & Molecular Biology

The gap junction cellular internet: connexin hemichannels enter the signalling limelight

W. Howard Evans et al.

BIOCHEMICAL JOURNAL (2006)

Article Multidisciplinary Sciences

Pannexin 1 in erythrocytes: Function without a gap

Silviu Locovei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Pharmacology & Pharmacy

Purinergic P2 receptors as targets for novel analgesics

Geoffrey Burnstock

PHARMACOLOGY & THERAPEUTICS (2006)

Review Biochemistry & Molecular Biology

Gap junctions and connexin-mediated communication in the immune system

E Oviedo-Orta et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)

Article Clinical Neurology

Spinal gap junctions: Potential involvement in pain facilitation

LE Spataro et al.

JOURNAL OF PAIN (2004)

Article Biochemistry & Molecular Biology

Connexin30 mutations responsible for hidrotic ectodermal dysplasia cause abnormal hemichannel activity

GM Essenfelder et al.

HUMAN MOLECULAR GENETICS (2004)

Article Biochemistry & Molecular Biology

Pannexin membrane channels are mechanosensitive conduits for ATP

L Bao et al.

FEBS LETTERS (2004)

Article Biochemistry & Molecular Biology

P2X7 receptor inhibition improves recovery after spinal cord injury

XH Wang et al.

NATURE MEDICINE (2004)

Article Multidisciplinary Sciences

Pannexins, a family of gap junction proteins expressed in brain

R Bruzzone et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Neurosciences

New roles for astrocytes:: Gap junction hemichannels have something to communicate

MVL Bennett et al.

TRENDS IN NEUROSCIENCES (2003)

Review Physiology

Gap junction hemichannels in astrocytes of the CNS

JC Sáez et al.

ACTA PHYSIOLOGICA SCANDINAVICA (2003)

Article Multidisciplinary Sciences

A heat-sensitive TRP channel expressed in keratinocytes

AM Peier et al.

SCIENCE (2002)

Article Biochemistry & Molecular Biology

Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels

CE Stout et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Functional vanilloid receptors in cultured normal human epidermal keratinocytes

K Inoue et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Biochemistry & Molecular Biology

Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord

JE Rash et al.

CELL COMMUNICATION AND ADHESION (2001)