Journal
PROGRESS IN NEUROBIOLOGY
Volume 209, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2021.102199
Keywords
Stroke; Recovery; Reactive gliosis; Intermediate filaments (nanofilaments); MRI; Functional connectivity
Categories
Funding
- Friebe Foundation [T0498/28960/16]
- Swedish Medical Research Council [2017-02255, 2017-00991]
- ALF Gothenburg [724421, 716591]
- Sodderbergs' Foundations
- Hjadrnfonden
- Amlodv's Foundation
- Swedish Stroke Foundation
- EU FP 7 Program TargetBraIn [279017]
- Hagstrodmer's Foundation Millennium
- E. Jacobson's Donation Fund
- EuroCellNet COST Action [CA15214]
- Vinnova [2017-00991, 2017-02255] Funding Source: Vinnova
- Swedish Research Council [2017-00991, 2017-02255] Funding Source: Swedish Research Council
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The restoration of functional connectivity is crucial for functional recovery after stroke. This study investigated the role of reactive astrocytes in functional connectivity and recovery after ischemic stroke.
Restoration of functional connectivity is a major contributor to functional recovery after stroke. We investigated the role of reactive astrocytes in functional connectivity and recovery after photothrombotic stroke in mice with attenuated reactive gliosis (GFAP(-/-)Vim(-/-)). Infarct volume and longitudinal functional connectivity changes were determined by in vivo T2-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Sensorimotor function was assessed with behavioral tests, and glial and neural plasticity responses were quantified in the peri-infarct region. Four weeks after stroke, GFAP(-/-)Vim(-/-) mice showed impaired recovery of sensorimotor function and aberrant restoration of global neuronal connectivity. These mice also exhibited maladaptive plasticity responses, shown by higher number of lost and newly formed functional connections between primary and secondary targets of cortical stroke regions and increased peri-infarct expression of the axonal plasticity marker Gap43. We conclude that reactive astrocytes modulate recovery-promoting plasticity responses after ischemic stroke.
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