Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 111, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2021.110390
Keywords
Cocaine; Cannabidiol; Place conditioning; Locomotor stimulation; Withdrawal; Mice
Funding
- Ministerio de Ciencia, Innovacion y Universidades, Spain [PSI2017-83023]
- Red Tematica de Investigacion Cooperativa en Salud (RETICS)
- Red de Trastornos Adictivos (RTA) [RD16/0017/0007]
- Instituto de Salud Carlos III, MICINN
- FEDER, Madrid, Spain
- Conselleria dEducacio, Investigacio, Cultura i Esport, Generalitat Valenciana, Spain [APOSTD/2016/147]
Ask authors/readers for more resources
The study reveals that CBD does not affect the acquisition, expression, and extinction of cocaine addiction, but can prevent priming-induced reinstatement of conditioned place preference during the extinction phase. Additionally, CBD can reduce cocaine-induced hyperactivity and memory deficits, but does not reverse depressive-like symptoms.
Cocaine dependence is a highly prevalent disease in modern society and lacks an effective treatment. Cannabidiol (CBD), a major non-psychoactive constituent of Cannabis sativa, has been shown to be a promising tool in the management of some neuropsychiatric disorders, including cocaine abuse. However, its therapeutic effects on the behavioral outcomes related to cocaine addiction remain unclear. The present research evaluates the effects of CBD (30, 60 and 120 mg/kg; injected intraperitoneally) on the acquisition, expression, extinction and reinstatement of cocaine (10 mg/kg)-induced conditioned place preference (CPP; Study 1); cocaine (25 mg/kg)-induced locomotor stimulation (Study 2); and cocaine withdrawal symptoms (Study 3) in male C57BL/6 J mice. The results show that CBD does not possess motivational properties in itself and does not modify the acquisition, expression or extinction of cocaine-induced CPP. Interestingly, when administered during the extinction phase of the cocaine-induced CPP, CBD (30 and 60 mg/kg) prevented priming-induced reinstatement of CPP. Moreover, CBD abolished cocaine-induced hyperactivity without altering the spontaneous locomotion of the animals. Furthermore, CBD (120 mg/kg) reduced the memory deficits induced by cocaine withdrawal in the object recognition test, though it did not reverse depressive-like symptoms measured in the tail suspension test. Overall, our data suggest that CBD can prevent the development of cocaine addiction, and, when administered during cocaine abstinence, may be of help in avoiding relapse to drug-seeking and in ameliorating the memory disturbances provoked by chronic consumption of cocaine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available