4.8 Article

Hobit confers tissue-dependent programs to type 1 innate lymphoid cells

Related references

Note: Only part of the references are listed.
Review Immunology

Innate lymphoid cells: from helper to killer

Lisette Krabbendam et al.

Summary: ILCs consist of LTi cells, NK cells, ILC1, ILC2, and ILC3, with helper ILCs producing potent cytokines and possessing the ability to switch function and phenotype in response to environmental changes. Recent research indicates the presence of cytotoxic helper ILCs, which can develop from conventional ILCs in humans but require further elucidation in mice.

CURRENT OPINION IN IMMUNOLOGY (2021)

Review Immunology

Natural killers or ILC1s? That is the question

Cyril Seillet et al.

Summary: ILC1 and NK cells share common features but have great heterogeneity in tissues, posing a challenge in distinguishing between the two cell types.

CURRENT OPINION IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Skin-resident innate lymphoid cells converge on a pathogenic effector state

Piotr Bielecki et al.

Summary: This study reveals that induction of psoriasis in mice by IL-23 or imiquimod leads to a reconfiguration of skin ILCs towards a pathogenic ILC3-like state. Skin ILCs exhibit a range and flexibility in their responses, indicating that immune activities primed in healthy tissues dynamically adapt to provocations and, left unchecked, drive pathological remodelling.

NATURE (2021)

Review Immunology

Natural Killer Cells: From Innate to Adaptive Features

Adriana M. Mujal et al.

Summary: NK cells play a crucial role in host defense against pathogens and cancer, known for their early and rapid effector activity and ability to undergo adaptive immune processes. NK cells exhibit flexibility in both innate and adaptive responses, showcasing their versatility in human NK cell-mediated immunity.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Article Immunology

Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

Adelle P. McFarland et al.

Summary: NK cells and ILC1s are heterogenous innate lymphocytes characterized by specific gene expression programs in different tissues, including blood, spleen, and solid tumors. The programs of circulating NK cells were found to be reshaped in tumor-bearing mice, with conserved signatures similar to human NK cells. This study advances the understanding of the NK-ILC1 spectrum in both murine and human systems.

IMMUNITY (2021)

Article Multidisciplinary Sciences

Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop

Lu Bai et al.

Summary: Research indicates that the adult mouse liver contains lineage-CD122(+)CD49a(+) progenitor cells for liver ILC1s derived from fetal liver. The production of IFN-gamma by liver ILC1s themselves promotes their development in situ, emphasizing the role of extramedullary hematopoiesis in liver immune composition.

SCIENCE (2021)

Article Immunology

Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver

Chiara Di Censo et al.

Summary: Liver ILC1 exhibit heterogeneity in the expression of distinct effector molecules and surface receptors, with a subset expressing high levels of granzyme A enriched in adult mice. The heterogeneity of GzmA and CD160 expression in hepatic ILC1 begins perinatally and increases with age. ILC1 characterized by the expression of GzmA and CD160 show graded cytotoxic potential and ability to produce IFN-gamma, indicating functional diversification.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Immunology

Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues

Christin Friedrich et al.

Summary: ILC1 cells exhibit similar differentiation pathways in different organs, with a gradual loss of TCF-1 resulting in loss of proliferative potential and increased expression of effector molecules.

NATURE IMMUNOLOGY (2021)

Article Immunology

Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes

Loreto Parga-Vidal et al.

Summary: Tissue-resident memory CD8(+) T cells (T-RM) are a noncirculating memory T cell subset that provides early protection against reinfection. Hobit expression is up-regulated in a subset of LCMV-specific CD8(+) T cells within peripheral tissues, identified as T-RM precursors, with a biased contribution to the T-RM lineage. Transcriptional profiling of Hobit(+) effector T cells revealed the early establishment of T-RM properties.

SCIENCE IMMUNOLOGY (2021)

Review Immunology

NK Cell Development in Times of Innate Lymphoid Cell Diversity

Vladislava Stokic-Trtica et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

Plasticity of innate lymphoid cell subsets

Suzanne M. Bal et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Immunology

Tissue-Resident T Cells and Other Resident Leukocytes

David Masopust et al.

Annual Review of Immunology (2019)

Review Immunology

True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity

Luke Riggan et al.

TRENDS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells

Patrick L. Collins et al.

Review Immunology

Functional interactions between innate lymphoid cells and adaptive immunity

Gregory E. Sonnenberg et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Immunology

T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1

Jiang Zhang et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

Article Medicine, Research & Experimental

Biallelic mutations in IRF8 impair human NK cell maturation and function

Emily M. Mace et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Biochemistry & Molecular Biology

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection

Orr-El Weizman et al.

Review Immunology

NK cells in host responses to viral infections

Viola C. Lam et al.

CURRENT OPINION IN IMMUNOLOGY (2017)

Review Immunology

Ly49 receptors: evolution, genetic diversity, and impact on immunity

Mir Munir A. Rahim et al.

IMMUNOLOGICAL REVIEWS (2015)

Article Multidisciplinary Sciences

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

Georg Gasteiger et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Christoph S. N. Klose et al.

Article Immunology

Nfil3 is required for the development of all innate lymphoid cell subsets

Cyril Seillet et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Article Immunology

Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens

Theresa L. Geiger et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Article Immunology

Cutting Edge: Salivary Gland NK Cells Develop Independently of Nfil3 in Steady-State

Victor S. Cortez et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

A committed precursor to innate lymphoid cells

Michael G. Constantinides et al.

NATURE (2014)

Review Immunology

Complexity and divers y of he NKR-P1:Clr (Klrb1:Clec2) recognition systems

Christina L. Kirkham et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells

Christoph S. N. Klose et al.

NATURE (2013)

Article Multidisciplinary Sciences

Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity

Marina Cella et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Immunology

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Shintaro Kamizono et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)