Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 2, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2107833119
Keywords
air pollution; air quality; dementia; incidence; epidemiology
Categories
Funding
- National Institutes of Environmental Health Sciences [5P30ES007048]
- Alzheimer's Disease Research Center at the University of Southern California [P50AG005142, P30AG066530]
- Alzheimer's Association [AARF-19-591356]
- US EPA [RD831697, RD-83830001]
- Wake Forest Alzheimer's Disease Core Center [P30AG049638-01A1]
- Intramural Research Program, National Institute on Aging, NIH
- National Heart, Lung, and Blood Institute, NIH, US Department of Health and Human Services [HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, HHSN268201600004C]
- [R01AG033078]
- [RF1AG054068]
- [R01ES025888]
- [P01AG055367]
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Improving air quality in old age is associated with a lower risk of dementia in older women.
Late-life ambient air pollution is a risk factor for brain aging, but it remains unknown if improved air quality (AQ) lowers dementia risk. We studied a geographically diverse cohort of older women dementia free at baseline in 2008 to 2012 (n = 2,239, aged 74 to 92). Incident dementia was centrally adjudicated annually. Yearly mean concentrations of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) were estimated using regionalized national universal kriging models and averaged over the 3-y period before baseline (recent exposure) and 10 y earlier (remote exposure). Reduction from remote to recent exposures was used as the indicator of improved AQ. Cox proportional hazard ratios (HRs) for dementia risk associated with AQ measures were estimated, adjusting for sociodemographic, lifestyle, and clinical characteristics. We identified 398 dementia cases during follow up (median = 6.1 y). PM2.5 and NO2 reduced significantly over the 10 y before baseline. Larger AQ improvement was associated with reduced dementia risks (HRPM2.5 0.80 per 1.78 mu g/m3, 95% CI 0.71-0.91; HRNO2 0.80 per 3.91 parts per billion, 95% CI 0.71-0.90), equivalent to the lower risk observed in women 2.4 y younger at baseline. Higher PM2.5 at baseline was associated with higher dementia risk (HRPM2.5 1.16 per 2.90 mu g/m3, 95% CI 0.98-1.38), but the lower dementia risk associated with improved AQ remained after further adjusting for recent exposure. The observed associations did not substantially differ by age, education, geographic region, Apolipoprotein E e4 genotypes, or cardiovascular risk factors. Long-term AQ improvement in late life was associated with lower dementia risk in older women.
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