Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 49, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2116125118
Keywords
brown adipose tissue; acetate; obesity; RNA-seq
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Funding
- Swiss National Science Foundation (SNSF) [185011, SNSF 191874, SNSF 191829]
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The study reveals that local acetate directly inhibits brown adipose tissue thermogenesis, decreases energy expenditure, and down-regulates genes related to the tricarboxylic acid cycle and brown adipocyte formation.
Brown adipose tissue has been extensively studied in the last decade for its potential to counteract the obesity pandemic. However, the paracrine regulation within brown tissue is largely unknown. Here, we show that local acetate directly inhibits brown fat thermogenesis, without changing acetate levels in the circulation. We demonstrate that modulating acetate within brown tissue at physiological levels blunts its function and systemically decreases energy expenditure. Using a series of transcriptomic analyses, we identified genes related to the tricarboxylic acid cycle and brown adipocyte formation, which are down-regulated upon local acetate administration. Overall, these findings demonstrate that local acetate inhibits brown fat function.
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