Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 6, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2117300119
Keywords
prefrontal cortex; spatial representation; topographical organization; dynamics of representation
Categories
Funding
- German Research Foundation (Deutsche Forschungsgemeinschaft) [BA1582/12-1, FOR2143, FOR5159 TP07, SA3609/1-1]
- European Research Council [ERC-AdG 787450]
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The study reveals the emergence of a dynamic and topographically organized place code in the medial prefrontal cortex of mice during spontaneous locomotion. This representation discriminates between familiar and novel environments and is reinstated upon reexposure to the same familiar environment. The topographical analysis shows a dorsoventral gradient in the representation of the own position, which is opposite to the innervation density of hippocampal inputs.
Spatial tuning of neocortical pyramidal cells has been observed in diverse cortical regions and is thought to rely primarily on input from the hippocampal formation. Despite the well-studied hippocampal place code, many properties of the neocortical spatial tuning system are still insufficiently understood. In particular, it has remained unclear how the topography of direct anatomical connections from hippocampus to neocortex affects spatial tuning depth, and whether the dynamics of spatial coding in the hippocampal output region CA1, such as remapping in novel environments, is transmitted to the neocortex. Using mice navigating through virtual environments, we addressed these questions in the mouse medial prefrontal cortex, which receives direct input from the hippocampus. We found a rapidly emerging prefrontal representation of space in the absence of task rules, which discriminates familiar from novel environments and is reinstated upon reexposure to the same familiar environment. Topographical analysis revealed a dorsoventral gradient in the representation of the own position, which runs opposite to the innervation density of hippocampal inputs. Jointly, these results reveal a dynamically emerging and topographically organized prefrontal place code during spontaneous locomotion.
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