Journal
INORGANIC CHEMISTRY
Volume 55, Issue 24, Pages 12618-12625Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.6b01660
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Funding
- NSF [CHE-1454747, CHE-0923589, CHE-1427987]
- Sloan Foundation
- Dreyfus Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1454747] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1427987] Funding Source: National Science Foundation
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Hydrogen sulfide (H2S) and nitric oxide (NO) are important biosignaling molecules, and their biochemistries are increasingly recognized to be intertwined. Persulfides are an oxidized product of biological H2S and have emerged as important species involved in the biological action of reactive sulfur species. Using isolated persulfides, we employed a combination of experimental and computational methods to investigate the contribution of persulfides to H2S/NO crosstalk. Our studies demonstrate that isolated persulfides react with nitrite to produce NO via polysulfide and perthionitrite intermediates. These results highlight the importance of persulfides, polysulfides, and perthionitrite as intertwined reactive nitrogen and sulfur species.
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