Journal
POLYMER REVIEWS
Volume 62, Issue 3, Pages 626-651Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15583724.2021.2014519
Keywords
Sequence-defined polymers; DNA mimicry; molecular ladder; synthetic polymer; templating; replication
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Funding
- U.S. Department of Energy, Office of Science, Basic Energy Sciences [DE-SC0012479]
- National Science Foundation [1462267]
- National Science Foundation Graduate Research Fellowship Program
- National Institutes of Health [R01 DE026116]
- Directorate For Engineering [1462267] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn [1462267] Funding Source: National Science Foundation
- U.S. Department of Energy (DOE) [DE-SC0012479] Funding Source: U.S. Department of Energy (DOE)
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Advances in synthetic chemistry have enabled abiotic, sequence-defined polymers to mimic the structures and functions of DNA, with a vast library of functionalities for tailored applications. Novel sequencing and conjugation methodologies have enhanced the versatility of discrete macromolecules.
Advances in synthetic chemistry have enabled abiotic, sequence defined polymers to imitate the structures and functions once exclusive to DNA. Indeed, the vast library of accessible backbones and pendant-group functionalities afford synthetic polymers an advantage over DNA in emerging applications as they can be tailored for stability or performance. Moreover, novel methodologies for sequencing and conjugation have been leveraged to elevate the versatility of discrete macromolecules. This review highlights abiotic, sequence-defined polymers in their capacity to mimic the primary functions of DNA - data storage and retrieval, sequence-specific self-assembly of duplexes, and replication and synthetic templating of new macromolecules.
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