Microwave-Assisted One-Pot Three Component Synthesis of Some Thiazolyl(Hydrazonoethyl)Thiazoles as Potential Anti-Breast Cancer Agents

In the present work, 1-(4-methyl-2-(2-(1-(thiophen-2-yl)ethylidene)hydrazinyl) thiazol-5-yl)ethanone was used as building block for synthesis of novel four series of 5-(1-(2-(thiazol-2-yl)hydrazono)ethyl) thiazole derivatives in a one-pot three-component reaction using both thermal heating and microwave irradiation for comparison. All the structures of the synthesized compounds were elucidated based on their elemental analyses and spectral measurements. The bioactivities of the synthesized compounds were evaluated their antitumor activities against MCF-7 tumor cells in comparison with vinblastine sulfate and cisplatin reference drugs using MTT assay and the results revealed promising activities of five compounds (4d, 8b, 12e, 4a, and 12d).

Automated summary

In this study, a novel series of thiazole derivatives were synthesized using 1-(4-methyl-2-(2-(1-(thiophen-2-yl)ethylidene)hydrazinyl) thiazol-5-yl)ethanone as a building block. Five compounds were found to exhibit promising antitumor activities against MCF-7 tumor cells, demonstrating potential as therapeutic agents.