Journal
PLOS ONE
Volume 16, Issue 11, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0259082
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Funding
- European Commission [ERC-2010-Ad268541]
- Research Council of Norway [275053]
- University of Oslo
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A hallmark of celiac disease is the production of antibodies specific for deamidated gluten peptides and transglutaminase 2, believed to result from B cells receiving help from gluten-specific CD4(+) T cells. This study demonstrates that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells, allowing both types of B cells to receive help from gluten-specific T cells of many different specificities.
A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4(+) T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4(+) T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities.
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