Journal
PLOS ONE
Volume 17, Issue 2, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0263228
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Funding
- Medical Research Council National Prevention Research Initiative [MR/J000493/1]
- Alzheimer's Research Trust
- Alzheimer's Society
- Biotechnology and Biological Sciences Research Council
- British Heart Foundation
- Cancer Research UK
- Chief Scientist Office
- Department of Health
- Diabetes 15 UK
- Economic and Social Research Council
- Health and Social Care Research and Development Division of the Public Health Agency (HSC RD Division)
- UK Medical Research Council (MRC)
- Stroke Association
- Welsh Assembly Government
- World Cancer Research Fund
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- NIHR Oxford and Thames Valley Applied Research Collaboration
- NIHR Academic Clinical Fellowship
- Scottish Government Health Directorate
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Objectives The aim was to investigate the impact of a group-based weight management programme on symptoms of depression and anxiety compared with self-help in a randomised controlled trial (RCT). Method People with overweight (Body Mass Index [BMI]>= 28kg/m(2)) were randomly allocated self-help (n = 211) or a group-based weight management programme for 12 weeks (n = 528) or 52 weeks (n = 528) between 18/10/2012 and 10/02/2014. Symptoms were assessed using the Hospital Anxiety and Depression Scale, at baseline, 3, 12 and 24 months. Linear regression modelling examined changes in Hospital Anxiety and Depression Scale between trial arms. Results At 3 months, there was a -0.6 point difference (95% confidence interval [CI], -1.1, -0.1) in depression score and -0.1 difference (95% CI, -0.7, 0.4) in anxiety score between group-based weight management programme and self-help. At subsequent time points there was no consistent evidence of a difference in depression or anxiety scores between trial arms. There was no evidence that depression or anxiety worsened at any time point. Conclusions There was no evidence of harm to depression or anxiety symptoms as a result of attending a group-based weight loss programme. There was a transient reduction in symptoms of depression, but not anxiety, compared to self-help. This effect equates to less than 1 point out of 21 on the Hospital Anxiety and Depression Scale and is not clinically significant.
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