Journal
PLASMA PROCESSES AND POLYMERS
Volume 19, Issue 7, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.202100246
Keywords
antibacterial efficacy; biocompatibility; catalytic activity; metal oxides; ROS generation
Funding
- Innosuisse - Swiss Innovation Agency [30078.1 IP-LS]
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In this study, plasma technology was used to deposit Ag nano islets on defective TiOx films for rapid antibacterial effects, with ROS generation maintained and restored by exposure to visible light. The study found that the rapid-acting antibacterial properties strongly correlate with ROS generation, which can be maintained by functionalization with hydrophobic plasma polymer films. These cytocompatible coatings offer promising applications for implants and other medical devices.
To enable a rapid-acting antibacterial mechanism without the release of biocidal substances, TiO2 catalysts have been considered based on the generation of reactive oxygen species (ROS). Doping with dissimilar metals generates electron-hole pairs with narrow band gaps promoting the production of ROS. Here, plasma technology is investigated to deposit Ag nano islets on defective TiOx films, stabilized by plasma postoxidation suppressing Ag ion release. Importantly, ROS generation is maintained upon storage in the dark yet with diminishing efficacy; however, it can be restored by exposure to visible light. The rapid-acting antibacterial properties are found to strongly correlate with ROS generation, which can even be maintained by functionalization with hydrophobic plasma polymer films. The cytocompatible coatings offer promising applications for implants and other medical devices.
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