4.5 Article

Toward defining plasma treatment dose: The role of plasma treatment energy of pulsed-dielectric barrier discharge in dictating in vitro biological responses

Journal

PLASMA PROCESSES AND POLYMERS
Volume 19, Issue 3, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.202100151

Keywords

cancer treatment; non-thermal plasma; plasma energy; plasma medicine; plasma treatment dose

Funding

  1. Fonds Wetenschappelijk Onderzoek [12S9218N, 12S9221N, G044420N]

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This study investigated the energy dependence of a pulsed-dielectric barrier discharge plasma treatment on chemical species production and biological responses. The results suggest that the delivered plasma energy plays a predominant role in stimulating a biological response in vitro, aiding in developing steps toward defining a plasma treatment unit and treatment dose for biomedical and clinical research.
The energy dependence of a pulsed-dielectric barrier discharge (DBD) plasma treatment on chemical species production and biological responses was investigated. We hypothesized that the total plasma energy delivered during treatment encompasses the influence of major application parameters. A microsecond-pulsed DBD system was used to treat three different cancer cell lines and cell viability was analyzed. The energy per pulse was measured and the total plasma treatment energy was controlled by adjusting the pulse frequency, treatment time, and application distance. Our data suggest that the delivered plasma energy plays a predominant role in stimulating a biological response in vitro. This study aids in developing steps toward defining a plasma treatment unit and treatment dose for biomedical and clinical research.

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