Journal
INNATE IMMUNITY
Volume 22, Issue 3, Pages 181-185Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753425916636671
Keywords
Mycobacteria; Mincle; IL-10; macrophage; receptor
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Funding
- Wellcome Trust UK [WT082825]
- German 'Bundesministerium fur Bildung und Forschung' (BMBF) program 'Medical Infection Genomics' [0315834C-D]
- Wellcome Trust
- Royal Society Sir Henry Dale Fellowship [099953/Z/12/Z]
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The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
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