Use of intravoxel incoherent motion MRI to assess placental perfusion in normal and Fetal Growth Restricted pregnancies on their third trimester

Introduction: Intravoxel Incoherent Motion (IVIM) MRI is a non-invasive, in vivo techniques which can assess placental perfusion quantitatively, and be useful for evaluating placental microcirculation. Our primary aim was to investigate whether fetal growth restriction (FGR) pregnancies have different placental perfusion and diffusion compared with normal pregnancies using IVIM. A secondary aim was to investigate correlations between placental IVIM parameters and gestational age in normal pregnancy. Methods: This study population included 17 FGR pregnancies and 36 normal pregnancies between 28 + 3 to 38 + 0 weeks. All women underwent a MRI examination including an IVIM sequence with 9 b-values on a 3.0 T MRI system. The standard diffusion coefficeint (D), pseudodiffusion (D*) and perfusion fraction (f) were calculated. Results: Placental f was significantly lower in the FGR group than that in the normal group (33.96 +/- 2.62(%) vs 38.48 +/- 5.31(%), p = 0.002). Placental D and D* in two groups showed no statistical significance (P > 0.05). Placental f moderately increased with increasing gestational age in normal pregnancies (r = 0.411, p = 0.013), and there existed a negative correlation between D values and gestational age (r = -0.390, p = 0.019). Discussion: The f values are able to distinguish FGR from normal pregnancies. It can be uses as a feasible index to evaluate placenta perfusion. Gestational age-associated changes in placental IVIM parameters likely reveal trajectories of microvascular perfusion fraction and diffusion characteristics in the normal developing placenta.

Automated summary

This study investigated the differences in placental perfusion and diffusion between fetal growth restriction (FGR) pregnancies and normal pregnancies using Intravoxel Incoherent Motion (IVIM) MRI. The results showed that the placental perfusion fraction (f) was significantly lower in the FGR group compared to the normal group, while diffusion coefficients (D) and pseudodiffusion (D*) showed no significant differences. Additionally, there was a positive correlation between placental f and gestational age in normal pregnancies, and a negative correlation between placental D values and gestational age.