Journal
PLACENTA
Volume 118, Issue -, Pages 66-69Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2022.01.008
Keywords
Extracellular vesicle; Exosome; Microvesicle; Antiphospholipid; Placenta; Lupus anticoagulant
Funding
- Auckland Medical Research Foundation
- Health Research Council of New Zealand
- Hub of Extracellular Vesicle Investigations, University of Auckland
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Antiphospholipid antibodies (aPL) may contribute to pregnancy disorders such as recurrent miscarriage, preeclampsia, and stillbirths by altering the cargo and targeting of placental extracellular vesicles (EVs).
Antiphospholipid antibodies (aPL) are autoantibodies that cause pregnancy disorders by a poorly defined mechanism that involves the placenta. The human placenta is covered by a single multinucleated cell, the syncytiotrophoblast, which extrudes vast numbers of extracellular vesicles (EVs) into the maternal blood. Extracellular vesicles are tiny packages of cellular material used by cells for remote signalling. In normal pregnancy, placental EVs assist maternal adaptations to pregnancy. We have previously shown that aPL alter the cargo of placental EVs, increasing the load of danger signals. These changes in EV cargo may explain how aPL contribute to the increased risk of recurrent miscarriage, preeclampsia and stillbirths observed in aPL-affected pregnancies. An additional possibility, that aPL alters the targeting of placental EVs to maternal organs to cause maternal maladaptation to pregnancy was investigated in this study.
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