Journal
PHYTOTHERAPY RESEARCH
Volume 36, Issue 2, Pages 873-890Publisher
WILEY
DOI: 10.1002/ptr.7371
Keywords
Aloin; antibacterial; antiinflammatory; antioxidant; antitumor
Categories
Funding
- Innovative Research Teams Program II of Fujian Normal University in China [IRTL1703]
- Marine Economic Development Subsidy Fund Project of Fujian Province [FJHJF-L2020-2]
- National Natural Science Foundation of China [81803547]
- Natural Science Foundation of Fujian Province [2021J01204]
- Special Sci-tech Team Commissioner of Fujian province [T202005007, T202005013]
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Aloin, an active ingredient found in Aloe species, has attracted considerable interest for its anti-inflammatory, anticancer, antibacterial, and antioxidant activities. However, its unclear mechanism of action restricts its clinical application, highlighting the need for a deeper understanding of its pharmacological activity and the development of new research approaches.
The Aloe species is known for its medicinal and cosmetic properties. Aloin is an active ingredient found in the leaves of medicinal plants of the genus Aloe. Aloin has attracted considerable interest for its antiinflammatory, anticancer, antibacterial, and antioxidant activities. However, since its clinical application is restricted by its unclear mechanism of action, a deeper understanding of its pharmacological activity is required. This review provides an overview of current pharmacological and toxicological studies published in English from February 2000 to August 2021. Herein, we summarized the sources and potential health benefits of aloin from a clinical application perspective to guide for further studies on the sources of aloin, aimed at efficiently increasing aloin production. Importantly, the function and mechanism of action of aloin remain unclarified. In future research, it is necessary to develop new approaches for studying the pharmacological molecular mechanisms underlying the activity of this compound against various diseases.
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