Journal
PHYTOTHERAPY RESEARCH
Volume 36, Issue 1, Pages 214-230Publisher
WILEY
DOI: 10.1002/ptr.7306
Keywords
antiinflammatory effects; antioxidative effects; lipid regulation; maintenance of mitochondrial function; polydatin; regulation of autophagy and apoptosis
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Funding
- Hundred Talents Program of the Hospital of Chengdu University of TCM [20-Y17]
- Beijing Medical and Health Foundation [YWJKJJHKYJJ-B20645FN]
- National Natural Science Foundation of China [81874365, 81703725]
- Science Foundation of Sichuan Education Department [18ZA0186]
- Sichuan Science and Technology Program [2019YJ0492]
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Polydatin (PD) is a natural product extracted from Polygonum cuspidatum Sieb. et Zucc, with various biological activities. It is likely to be used in cardiac and cerebral ischemia-related diseases, and atherosclerosis. PD shows therapeutic effects primarily through antioxidative, antiinflammatory, autophagy and apoptosis regulation, maintenance of mitochondrial function, and lipid regulation mechanisms.
Polydatin (PD) is a natural single-crystal product that is primarily extracted from the traditional plant Polygonum cuspidatum Sieb. et Zucc. Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion-related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. In summary, we found that PD played a therapeutic role in a variety of diseases, primarily via five mechanisms: antioxidative effects, antiinflammatory effects, regulation of autophagy and apoptosis, maintenance of mitochondrial function, and lipid regulation.
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