Journal
PHYTOMEDICINE
Volume 93, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2021.153799
Keywords
Natural product; Proteasome; Ubiquitin; Protein; Regulation
Categories
Funding
- National Natural Science Foundation of China [82174023, 81773941, 81903654]
- National Key Subject of Drug Innovation, China [2019ZX09201005-007]
- National key R&D program for key research project of modernization of traditional Chinese medicine [2019YFC1711602]
- Program for Professor of Special Appointment (Young Eastern Scholar) at Shanghai Institutions of Higher Learning, China
- Shanghai Chenguang Program of Education Commission of Shanghai Municipality, China [18CG46]
- Yangfan Program of Science and Technology Commission of Shanghai Municipality, China [19YF1449400]
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The study reviewed the pharmacological effects of more than 80 natural products and extracts related to proteasome regulation, classified them by their chemical properties, and summarized the laws of action of natural products as proteasome regulators in the treatment of diseases, which is important for the discovery of new proteasome regulators.
Background: Natural medicines have a long history in the prevention and treatment of various diseases in East Asian region, especially in China. Modern research has proved that the pharmacological effects of numerous natural medicines involve the participation of ubiquitin proteasome system (UPS). UPS can degrade the unwanted and damaged proteins widely distributed in the nucleus and cytoplasm of various eukaryotes. Purpose: The objective of the present study was to review and discuss the regulatory effects of natural products and extracts on proteasome components, which may help to find new proteasome regulators for drug development and clinical applications. Methods: The related information was compiled using the major scientific databases, such as CNKI, Elsevier, ScienceDirect, PubMed, SpringerLink, Wiley Online, and GeenMedical. The keywords natural product and proteasome were applied to extract the literature. Nature derived extracts, compounds and their derivatives involved in proteasome regulation were included, and the publications related to synthetic proteasome agents were excluded. Results: The pharmacological effects of more than 80 natural products and extracts derived from phytomedicines related to the proteasome regulation were reviewed. These natural products were classified according to their chemical properties. We also summarized some laws of action of natural products as proteasome regulators in the treatment of diseases, and listed the action characteristics of the typical natural products. Conclusion: Natural products derived from nature can induce the degradation of damaged proteins through UPS or act as regulators to directly regulate the activity of proteasome. But few proteasome modulators are applied clinically. Summary of known rules for proteasome modulators will contribute to discover, modify and synthesize more proteasome modulators for clinical applications.
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