Journal
PHYTOCHEMISTRY
Volume 191, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2021.112904
Keywords
Ophiopogon japonicus; Asparagaceae; Seed; Anacardic acid derivatives; Neuroprotective activity
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Funding
- JSPS KAKENHI [21K05289]
- Grants-in-Aid for Scientific Research [21K05289] Funding Source: KAKEN
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Eight new long-chain anacardic acid derivatives, janohigenins, were isolated from the endosperm of Ophiopogon japonicus seed. The compounds showed noticeable neuroprotection at 1 mu M against rotenone-induced cellular damage in SH-SY5Y human neuroblastoma cells. This study suggests potential neuroprotective effects of janohigenins.
Eight hitherto undescribed long-chain anacardic acid derivatives, janohigenins, were isolated from the endosperm of Ophiopogon japonicus seed, and their structures were elucidated employing spectroscopic and chemical methods. The neuroprotective activity of the isolated compounds was evaluated against rotenone-induced cellular damage in SH-SY5Y human neuroblastoma cells. Janohigenins exhibited noticeable neuroprotection at 1 mu M.
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