Journal
PHYTOCHEMISTRY
Volume 192, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2021.112927
Keywords
Sesquiterpenoids; Bisabolane-type; Distribution; Phytochemistry; Biological activity
Categories
Funding
- National Natural Science Foundation of China (NNSFC) [82022072, 81903777]
- Sichuan Science and Technology Program [2019YJ0334, 2018JZ0081]
- Xinglin Scholar Plan of Chengdu University of Traditional Chinese Medicine [YXRC2018005, BSH2018009, QNXZ2019030]
- Open Research Fund of Chengdu University of Traditional Chinese Medicine and Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China [2020BSH006, 2020XSGG015, 2020BSH013]
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Bisabolane-type sesquiterpenoids are a class of monocyclic sesquiterpenoids widely distributed in nature, with antibacterial, anti-inflammatory, and cytotoxic effects being the most commonly reported pharmacological properties. These compounds have been used in traditional medicines for a long time and show great potential for the development of new drugs.
Bisabolane-type sesquiterpenoids, a class of monocyclic sesquiterpenoids, are widely distributed in nature and have a variety of biological activities. To provide a reference for the further research and development of these compounds, the phytochemical and biological properties of natural bisabolane-type sesquiterpenoids (356 compounds in total) isolated between 1985 and 2020 from 24 families, primarily Compositae, Zingiberaceae, Aspergillaceae, Halichondriidae, and Aplysiidae were reviewed. In vitro and in vivo studies have indicated that antibacterial, anti-inflammatory, and cytotoxic effects are the most commonly reported pharmacological properties of bisabolane-type sesquiterpenoids. Owing to their extensive significant effects, a lot of traditional medicines containing this type of compounds have been used for a long history. Thus, bisabolane-type sesquiterpenoids are a rich source of important natural products, which show great potential for the development of new drugs.
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