Journal
PHYTOCHEMISTRY
Volume 191, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2021.112926
Keywords
Salvia abrotanoides; Lamiaceae; Biosynthetic pathways; Antiproliferative activity; Seco-norabietane diterpene; Abrotafuran; Abrotacid
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Funding
- Ministry of Science, Research and Technology of Iran (MSRT)
- Shahid Beheshti University Research Council
- Department of Pharmacy, University of Salerno
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Two seco-norabietane diterpenes, abrotafuran and abrotacid, were isolated from Salvia abrotanoides roots. Abrotafuran exhibited antiproliferative activity on HeLa and Jurkat cell lines.
Two seco-norabietane diterpenes with unique structures, namely abrotafuran and abrotacid, were isolated from the roots of Salvia abrotanoides (Kar.) Sytsma. The compounds were characterized by 1D and 2D NMR spectroscopic techniques, ECD, and HR-ESIMS experiments. Plausible biosynthetic pathways of abrotafuran and abrotacid were proposed. These compounds did not exhibit antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. However, the rearranged seco-norabietane abrotafuran showed antiproliferative activity on HeLa (cervical carcinoma) and Jurkat (T-cell leukemia) cell lines.
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