Journal
PHYSIOLOGY & BEHAVIOR
Volume 241, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2021.113567
Keywords
Preeclampsia; HELLP; Sensorimotor; Behavior; Offspring; Neurodevelopment
Categories
Funding
- National Institutes of Health (NIH) [P20GM121334, R01MH116027, T32HL105324]
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Offspring born to dams with PreE and HELLP show evidence of early onset neurodevelopmental delay, with male HELLP offspring exhibiting altered behavior in some sensorimotor tests compared to other groups.
Offspring of Preeclampsia (PreE) and HELLP Syndrome are at an increased risk of developing neurodevelopmental disorders. In the current study we sought to determine if offspring from experimental models of PreE and HELLP had evidence of early onset neurodevelopmental delay. Offspring from PreE, HELLP and normal pregnant dams were assessed in a battery of sensorimotor tests beginning on postnatal day (PND) 3. Male HELLP offspring showed altered behavior in the surface righting reflex on PND 3 and cliff avoidance task from PND 3-6 relative to other groups. Results suggest that there are sex differences in offspring born to dams with PreE and HELLP.
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