4.6 Review

Emerging technologies in brachytherapy

Related references

Note: Only part of the references are listed.
Article Radiology, Nuclear Medicine & Medical Imaging

Fast Monte Carlo-Based Inverse Planning for Prostate Brachytherapy by Using Deep Learning

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Summary: We propose a fast inverse planning method for LDR prostate brachytherapy using a deep convolutional neural network (DCNN) to estimate the dose distribution. The method demonstrates comparable accuracy to Monte Carlo simulation (MCS) in tests, with a runtime of less than 1 minute.

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First report on the feasibility of a permanently implantable uni-directional planar low dose rate brachytherapy sheet for patients with resectable or borderline resectable pancreatic cancer

Joshua B. Dault et al.

Summary: This study utilized a novel implantable uni-directional LDR brachytherapy sheet to deliver a focal margin-directed high-dose boost in patients with concern for positive margins in resected pancreatic cancer. Results showed favorable clinical outcomes with high survival and disease-free rates without associated toxicity or complications.

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A novel minimally invasive dynamic-shield, intensity-modulated brachytherapy system for the treatment of cervical cancer

Marc Morcos et al.

Summary: A novel MRI-compatible dynamic shield intensity modulated brachytherapy (IMBT) applicator and delivery system has been proposed for the treatment of locally advanced cervical cancer. This technique significantly improves target coverage and organs at risk sparing compared to conventional radiotherapy techniques, showing promising dosimetric enhancements and improved therapeutic ratio.

MEDICAL PHYSICS (2021)

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Simultaneous needle catheter selection and dwell time optimization for preplanning of high-dose-rate brachytherapy of prostate cancer

Chao Wang et al.

Summary: The proposed algorithm in this study can select needle catheter positions and determine dwell time for preplanning of prostate cancer HDR brachytherapy, resulting in plans with increased median conformity index and slightly lower median homogeneity index, while reducing the number of selected needles.

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Knowledge-based inverse treatment planning for low-dose-rate prostate brachytherapy

Christian V. Guthier et al.

Summary: A novel knowledge-based (KB) optimization method was developed for generating clinically acceptable treatment plans for prostate cancer, reducing the need for manual adjustments. This method is able to generate high-quality treatment plans in under a minute, potentially reducing operating room time and anesthesia time.

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Optimization in treatment planning of high dose-rate brachytherapy - Review and analysis of mathematical models

Bjorn Moren et al.

Summary: Inverse planning is increasingly used in high dose-rate brachytherapy treatment planning, with various proposed optimization models. The mathematical optimization is utilized for decisions on catheter placement and dwell time distributions. The survey aims to give an overview of these models and provide comparisons, as well as suggest future research directions for clinical validation of optimization approaches.

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Robust optimization for HDR prostate brachytherapy applied to organ reconstruction uncertainty

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Summary: The study introduced a bi-objective optimization approach for HDR prostate brachytherapy plans, incorporating dose-volume indices. By examining different reconstruction settings, a robust optimization model was developed to address differences in 3D organ shape. Results showed that robust optimization improved plan quality without significantly increasing runtime.

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Characterization of combined intracavitary/interstitial brachytherapy including oblique needles in locally advanced cervix cancer

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Summary: This study characterized dosimetric outcomes of IGABT in LACC patients using IC/IS applicators with O-needles. Results showed that O-needles provided excellent target coverage and spared OARs in patients with large and/or unfavorable tumors. Comparatively, intrauterine and vaginal loadings were reduced, with almost half of the loading shifted to IS needles.

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Summary: This study aimed to improve dose distribution and organ-at-risk sparing in gynecologic HDR brachytherapy by using patient-specific applicators. Through Monte Carlo modeling, optimal biocompatible and sterilizable materials were selected for the applicator design. Patient-specific applicators showed superior dose modulation and healthy tissue sparing compared to generic designs, with comparable dose to the target.

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Shielded high dose rate ocular brachytherapy using Yb-169

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Byungdu Jo et al.

Summary: The study developed a robust optimization algorithm to minimize dose delivery uncertainties caused by potential applicator-positional errors in Cervix Brachytherapy, aiming to improve clinical outcomes. The robust optimization method utilized a genetic algorithm combined with a median absolute deviation as a robustness evaluation function, which may be worth considering according to the GEC-ESTRO guidelines.

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