Journal
PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS
Volume 16, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/pssr.202100496
Keywords
diffusion; drug solubility; graphene plasmons; indomethacin; molecular mobility; photothermal effects
Funding
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [103.01-2019.318]
- Vietnam Ministry of Education and Training [B2019-TNA-07]
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A theoretical approach is proposed to quantitatively determine the photothermally driven enhancement of molecular mobility of graphene-indomethacin mixtures under infrared laser irradiation. The temperature gradients of the bulk drug with different concentrations of graphene plasmons are calculated, from which the temperature dependence of structural molecular relaxation and diffusion of indomethacin is determined and the significant enhancement of drug mobility through the heating process is found out.
A theoretical approach to quantitatively determine the photothermally driven enhancement of molecular mobility of graphene-indomethacin mixtures under infrared laser irradiation is proposed. Graphene plasmons absorb incident electromagnetic energy and dissipate them into heat. The absorbed energy depends on optical properties of graphene plasmons, which are sensitive to structural parameters, and concentration of plasmonic nanostructures. By using theoretical modelling, temperature gradients of the bulk drug with different concentrations of graphene plasmons are calculated. From these, the temperature dependence of structural molecular relaxation and diffusion of indomethacin are determined and how the heating process significantly enhances the drug mobility is found out.
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