Ultrasound assisted synthesis of silver titanate for the differential pulse voltammetric determination of antibiotic drug metronidazole

Highly electroactive transition metal oxides have been received great potential in antibiotic drug electrochemical sensors due to excellent features including ease of preparation, a large number of active sites, good conductivity, high stability, and selectivity. In this work, the perovskite-type silver titanate (Ag2TiO3) was synthesized by ultrasound-assisted coprecipitation method. The structural and morphology were examined using typical analytical techniques such as X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FT-IR), Raman spectrometry, field-emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and X-ray photoelectron spectroscopy (XPS) analyzes confirmed the purity and the chemical composition of asprepared Ag2TiO3. The Brunauer-Emmett-Teller analysis (BET) of as-synthesized Ag2TiO3 displayed a specific surface area of 48.485 m(2) g(-1) resulted in improved charge transfer resistance (R-ct) of 695 Omega. The cyclic voltammetry (CV) analysis revealed the superior electrochemical performance of Ag2TiO3 than other electrodes towards metronidazole (MTZ) detection. Under optimized differential pulse voltammetric (DPV) studies, the modified electrode exhibits a wide linear range of 0.1-104.3 mu M with the lowest detection limit of 0.011 mu M and a sensitivity of 0.371 mu A mu M-1 cm(-2). Furthermore, the fabricated sensor displayed excellent cyclic stability, reproducibility, repeatability, and noticeable selectivity in potentially effective interfering compounds for the detection of MTZ. The constructed electrode delivered good sensitivity to MTZ in urine and tablet with acceptable recoveries.

Automated summary

The study successfully synthesized perovskite-type silver titanate (Ag2TiO3) using ultrasound-assisted coprecipitation method and conducted a series of structural and performance analyses. The results demonstrated that the prepared Ag2TiO3 exhibited excellent electrochemical performance, sensitivity, and selectivity in metronidazole detection.