4.7 Article

TLR4 and AT1R mediate blood-brain barrier disruption, neuroinflammation, and autonomic dysfunction in spontaneously hypertensive rats

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Summary: The mechanisms of intracranial pressure changes during hypertension remain unclear, especially in the 2K1C hypertensive model. This study found that as mean arterial pressure increased in 2K1C hypertensive rats, intracranial pressure also significantly increased with changes in pulse waveforms. Additionally, blood-brain barrier disruption in key central cardioregulatory nuclei was observed during the development of 2K1C hypertension. Losartan, an AT1R antagonist, partially reduced the increase in intracranial pressure in hypertensive rats, indicating that AT1R activation may play a role in elevated intracranial pressure during hypertension.

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