Journal
PHARMACOLOGICAL RESEARCH
Volume 174, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105966
Keywords
Microbiota; Cancer therapy; Immune microenvironment
Categories
Funding
- National Natural Science Foundation of China [82025016, 31830025]
- Natural Science Foundation of Guangdong Province, China [2018B030308010]
- Fundamental Research Funds for the Central Universities [19lgjc09]
Ask authors/readers for more resources
The impact of microbiota on disease progression varies depending on the tumor types, therapeutic regimens, and microbiota composition, highlighting the need for a deeper understanding of host-microbiome interactions. Gut microbiota influences disease progression by regulating local and systemic immunity, with intratumoral microbiota being an important component of the tumor microenvironment. The identification of intra-tumor microbiota and its role in immune microenvironment interaction may benefit current anti-cancer approaches.
Microbiota has been implicated in the regulation of tumor progression and therapeutic efficacy. However, the effect of microbiota on disease progression is context dependent, differing according to tumor types, therapeutic regimens, and composition of the microbiota, calling for a deeper understanding of host-microbiome interactions. Previous studies have demonstrated that gut microbiota influences disease progression by regulating local and systemic immunity. Notably, with the advent of next-generation sequencing technology, intratumoral microbiota has also been found and constitutes an important component of the tumor microenvironment. In this review, we summarize recent knowledge about the identification of intra-tumor microbiota and discuss the role of gut and intratumoral microbiota in solid tumors in the angle of immune microenvironment interaction. Furthermore, we discuss how these findings may benefit current anti-cancer approaches. Key problems to be solved in ongoing and future research are highlighted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available