Effects and mechanisms of dietary bioactive compounds on breast cancer prevention

Breast cancer (BC) is the most often diagnosed cancer among females globally and has become an increasing global health issue over the last decades. Despite the substantial improvement in screening methods for initial diagnosis, effective therapy remains lacking. Still, there has been high recurrence and disease progression after treatment of surgery, endocrine therapy, chemotherapy, and radiotherapy. Considering this view, there is a crucial requirement to develop safe, freely accessible, and effective anticancer therapy for BC. The dietary bioactive compounds as auspicious anticancer agents have been recognized to be active and their implications in the treatment of BC with negligible side effects. Hence, this review focused on various dietary bioactive com-pounds as potential therapeutic agents in the prevention and treatment of BC with the mechanisms of action. Bioactive compounds have chemo-preventive properties as they inhibit the proliferation of cancer cells, down-regulate the expression of estrogen receptors, and cell cycle arrest by inducing apoptotic settings in tumor cells.

Automated summary

Breast cancer is the most frequently diagnosed cancer among females globally, and the need for effective therapy is crucial. This review focuses on the potential therapeutic role of dietary bioactive compounds in the prevention and treatment of breast cancer, as they have shown promising effects with minimal side effects.