The molecular mechanism of vgf in appetite, lipids, and insulin regulation

Obesity is an indication of an imbalance between energy expenditure and food intake. It is a complicated disease of epidemic proportions as it involves many factors and organs. Sedentary lifestyles and overeating have caused a substantial rise in people with obesity and type 2 diabetes. Thus, the discovery of successful and sustainable therapies for these chronic illnesses is critical. However, the mechanisms of obesity and diabetes and the crosstalk between these diseases are still ambiguous. Numerous studies are being done to study these mechanisms, with updates made frequently. VGF peptide and its derivatives are anticipated to have a role in the development of obesity and diabetes. However, contradictory studies have produced conflicting findings on the function of VGF. Therefore, in this review, we attempt to clarify and explain the role of VGF peptides in the brain, pancreas, and adipose tissue in the development of obesity.

Automated summary

Obesity is a complex disease resulting from an imbalance between energy expenditure and food intake, with sedentary lifestyles and overeating contributing to a rise in obesity and type 2 diabetes cases. The mechanisms of these diseases and their interactions are still unclear, with ongoing research aiming to clarify these aspects. VGF peptide and its derivatives may play a role in the development of obesity and diabetes, though conflicting studies on the function of VGF have been reported.