Journal
PEDIATRIC DIABETES
Volume 23, Issue 4, Pages 462-468Publisher
WILEY-HINDAWI
DOI: 10.1111/pedi.13323
Keywords
accelerometer; autoimmunity; physical activity; type 1 diabetes
Categories
Funding
- American Diabetes Association
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institutes of Health
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The study aimed to investigate the relationship between physical activity and the progression of type 1 diabetes. By using an accelerometer to assess physical activity among children and youth at high-genetics risk for type 1 diabetes with islet autoimmunity, it was found that low-physical activity is not a risk factor for progressing from islet autoimmunity to diabetes.
Aims/Hypotheses Physical inactivity may contribute to islet autoimmunity and progression to clinical type 1 diabetes. To test this hypothesis, we evaluated physical activity, assessed by accelerometer, as an independent risk factor for progression to clinical diabetes among genetically at risk for type 1 diabetes children and youth with islet autoimmunity. Methods Accelerometer data were obtained for 95 children and youth participating in the diabetes autoimmunity study in the young who had islet autoimmunity. Islet autoimmunity was defined as the presence of islet autoantibodies to insulin, glutamic acid decarboxylase, tyrosine phosphatase-like protein IA-2, or zinc transporter 8. Results During prospective follow-up for up to 7 years, 13 of the 95 participants progressed to clinical diabetes. In multivariable survival analysis, none of the physical activity parameters examined predicted a higher risk of developing diabetes. In survival analysis with time-varying physical activity parameters, none of the physical activity parameters over time were associated with the risk of developing type 1 diabetes. Conclusions/Interpretation It does not appear that low-physical activity is a risk factor for progression from islet autoantibodies to diabetes in children and youth at high-genetic risk for type 1 diabetes.
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