4.5 Review

Contribution of circRNAs in gastric cancer

Related references

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Article Cell Biology

Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis

Ding Wang et al.

Summary: Recent research has shown that circ_HN1 acts as an oncogene in gastric cancer by upregulating ROCK2 through sponging miR-302b-3p. The study found that silencing circ_HN1 slowed tumor growth and inhibited malignant behaviors in GC cells, while miR-302b-3p inhibitor reversed these effects. Furthermore, overexpression of ROCK2 reversed the impacts of miR-302b-3p mimic on cell behaviors in GC cells.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway

Shuo Ma et al.

Summary: CircPTPN22 is upregulated in gastric cancer tissues, cells, and plasma, and positively correlated with metastasis. It can serve as a diagnostic marker and predict patient prognosis. CircPTPN22 inhibits cell proliferation and metastasis through competitive binding of miRNAs to regulate the EMT pathway.

CANCER CELL INTERNATIONAL (2021)

Article Cell Biology

Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/β-catenin pathway

Liyan Wang et al.

Summary: This study revealed that circ_SMAD4 promotes gastric cancer tumorigenesis by activating the CTNNB1-dependent Wnt/beta-catenin pathway. The mechanism involves nuclear circ_SMAD4 recruiting TCF4 to facilitate CTNNB1 transcription, while cytoplasmic circ_SMAD4 sequestering miR-1276 to prevent CTNNB1 mRNA silencing. Rescue experiments confirmed that circ_SMAD4 accelerates GC cell growth through the miR-1276/TCF4-regulated CTNNB1 pathway.

CELL PROLIFERATION (2021)

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Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer

Yuhai Zhang et al.

Summary: Recent studies have shown that the circular RNA hsa_circ_0076305 plays a crucial role in gastric cancer development by regulating cell proliferation and migration, indicating a potential target for cancer therapy.

ONCOLOGY LETTERS (2021)

Article Oncology

Circular RNA Circ_0006282 Promotes Cell Proliferation and Metastasis in Gastric Cancer by Regulating MicroRNA-144-5p/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein β Axis

Yunqi Hua et al.

Summary: Circular RNA circ_0006282 promotes malignant behaviors of gastric cancer cells by acting as a sponge for miR-144-5p to positively regulate YWHAB expression. Circ_0006282 knockdown inhibits tumor growth in vivo, indicating its potential as a therapeutic target for gastric cancer.

CANCER MANAGEMENT AND RESEARCH (2021)

Article Cell Biology

circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis

Xing Zhang et al.

Summary: The study revealed that circ_0005529 was upregulated in gastric cancer, promoting cell proliferation and migration by reducing miR-527 expression and affecting Sp1 regulation. This circ_0005529/miR-527/Sp1 axis shows potential as a novel therapeutic target for GC diagnosis and treatment, as demonstrated in mouse models.

BMC MOLECULAR AND CELL BIOLOGY (2021)

Article Oncology

Circular RNA hsa_circ_0072309 inhibits the proliferation, invasion and migration of gastric cancer cells via inhibition of PI3K/AKT signaling by activating PPARγ/PTEN signaling

Xingpo Guo et al.

Summary: hsa_circ_0072309 inhibits proliferation, invasion, and migration of gastric cancer cells via activation of the PPAR gamma/PTEN pathway and inhibition of the PI3K/AKT signaling pathway. Targeting hsa_circ_0072309 may be an innovative therapeutic strategy for the treatment of GC.

MOLECULAR MEDICINE REPORTS (2021)

Article Gastroenterology & Hepatology

Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis

Peng Deng et al.

Summary: The study reveals that circVAPA promotes chemotherapy resistance and malignant progression in gastric cancer through the miR-125b-5p/STAT3 signaling pathway. CircVAPA and miR-125b-5p may be considered as potential targets for gastric cancer therapy.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Circular RNA circAFF2 accelerates gastric cancer development by activating miR-6894-5p and regulating ANTXR 1 expression

Xuefeng Bu et al.

Summary: The study revealed that circAFF2 is overexpressed in gastric cancer cells and plays a crucial role in gastric cancer development; acting as a sponge for miR-6984-5p to elevate ANTXR 1 expression and promote tumor cell migration and invasion; in vivo experiments demonstrated that silencing circAFF2 could delay tumor growth.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2021)

Article Medical Laboratory Technology

Tumor suppressor role of hsa_circ_0035445 in gastric cancer

Weiliang Sun et al.

Summary: The circRNA hsa_circ_0035445 is found to be downregulated in gastric cancer tissues, plasma of patients, and cancer cells, with its expression level linked to tumor size and distant metastasis. The AUC of hsa_circ_0035445 in tissues and plasma were 0.68 and 0.86, respectively, indicating diagnostic value. Upregulation of hsa_circ_0035445 suppressed proliferation and migration, promoted apoptosis, while downregulation had the opposite effects.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Article Oncology

CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization

Yiwen Xia et al.

Summary: The study revealed that circFAM73A is upregulated in gastric cancer tissues and is associated with poor prognosis in patients. Upregulation of circFAM73A enhances cell proliferation, migration, cisplatin resistance, and CSC-like properties in gastric cancer. Mechanistically, circFAM73A promotes gastric cancer malignancy through the miR-490-3p/HMGA2 positive feedback loop and recruitment of HNRNPK.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Biotechnology & Applied Microbiology

Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis

Haifeng Gao et al.

Summary: The study found that in gastric cancer, hsa_circ_0000144 exerts inhibitory effects on oxaliplatin resistance, proliferation, and metastasis through regulating the miR-502-5p/ADAM9 axis.

ONCOTARGETS AND THERAPY (2021)

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Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis

Zhiyi Cheng et al.

Summary: This study found that circRNA_100395 was overexpressed in GC, while miR-142-3p expression was decreased. Low expression of circRNA_100395 was associated with poor tumor differentiation, advanced TNM stage, lymph node metastasis, and shorter overall survival time. Overexpression of circRNA_100395 suppressed cell proliferation, increased apoptosis rate, and inhibited cell invasion and migration by suppressing the PI3K/AKT signaling pathway. Additionally, circRNA_100395 had antitumor effects through the regulation of the miR-142-3p signaling pathway, potentially serving as a promising treatment target for GC.

ONCOLOGY LETTERS (2021)

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Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis

Qin Gao et al.

Summary: The study found that in gastric cancer cells, the expression of hsa_circ_0000117 is increased while miR-337-3p is decreased, along with an increase in STAT3 expression. Decreased hsa_circ_0000117 can inhibit proliferation and invasion of gastric cancer, and hsa_circ_0000117 acts as a sponge for miR-337-3p, working together with the miR-337-3p/STAT3 axis to exhibit oncogene properties.

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Circular RNA circ_0032821 contributes to oxaliplatin (OXA) resistance of gastric cancer cells by regulating SOX9 via miR-515-5p

Yanmei Zhong et al.

Summary: The study showed that circ_0032821 was highly expressed in OXA-resistant GC cells, and exosomes containing circ_0032821 could enhance resistance to OXA and promote proliferation in sensitive GC cells. By acting as a sponge of miR-515-5p to regulate SOX9 expression, circ_0032821 potentially serves as a promising therapeutic target for GC treatment by boosting OXA resistance.

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Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values

Xiuchong Yu et al.

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Clinical significance of hsa_circ_0000419 in gastric cancer screening and prognosis estimation

Xueping Tao et al.

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Hsa_circ_0001546 acts as a miRNA-421 sponge to inhibit the chemoresistance of gastric cancer cells via ATM/Chk2/p53-dependent pathway

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Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth

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CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149

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Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p

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CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification

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