Deep brain stimulation in a Parkinson's disease patient with calcifications and a mutation in the SLC20A2 gene

A patient with Parkinson's disease (PD) who was examined as a candidate for DBS was initially rejected due to extensive brain calcifications. Upon second opinion and planning of trajectories she underwent successful surgery. Genetic analyses identified a mutation in SLC20A2, a gene known to cause brain calcifications, but no mutation known to cause PD was found.

Automated summary

A patient with Parkinson's disease initially rejected for DBS due to extensive brain calcifications underwent successful surgery after seeking a second opinion. Genetic analysis revealed a mutation in the SLC20A2 gene, known to cause brain calcifications, but no known PD-causing mutation.