4.3 Review

Traditional Chinese Medicine Formulas Alleviate Acute Pancreatitis Pharmacological Activities and Mechanisms

Journal

PANCREAS
Volume 50, Issue 10, Pages 1348-1356

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPA.0000000000001931

Keywords

traditional Chinese medicine; formula; acute pancreatitis

Funding

  1. National Natural Science Foundation [82004291]
  2. Natural Science Foundation of Jiangsu Province [BK20190907]
  3. Six Talent Peaks Project of Jiangsu Province [WSN-325]
  4. Postdoctoral Science Foundation of China [2018M632260]

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Traditional Chinese medicine has unique advantages in treating acute pancreatitis, improving the condition of patients by regulating inflammatory responses and enhancing immunity, thereby reducing mortality rates and financial burdens.
Acute pancreatitis (AP) is a common clinical gastrointestinal disorder with a high mortality rate for severe AP and lacks effective clinical treatment, which leads to considerable comorbidity and financial burden. Traditional Chinese medicine (TCM) has had the unique advantage of treating AP for a long time in China. Clinically, TCM formulas such as Da-cheng-qi decoction, Chai-qin-cheng-qi decoction, Qing-yi decoction, Da-chai-hu decoction, and Da-huang-fu-zi decoction are widely administrated to AP patients. All of these TCM formulas can improve gastrointestinal function, regulate the inflammatory response, and enhance immunity, thus preventing complications, reducing the mortality rate and financial burden. This review will summarize the pharmacological activities and mechanisms of TCM formulas in alleviating AP.

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